PMID: 9420298Jan 7, 1998Paper

Gene arrangement within the unique long genome region of infectious laryngotracheitis virus is distinct from that of other alphaherpesviruses

Journal of Virology
K ZiemannW Fuchs

Abstract

The genome of the avian alphaherpesvirus infectious laryngotracheitis virus (ILTV) comprises ca. 155 kbp of which ca. one-third have been sequenced so far. To gain additional sequence information we analyzed two stretches of 15.5 and 1.9 kbp of the ILTV unique long (U(L)) genome region. The larger fragment contains homologs of the herpes simplex virus (HSV) UL23 (thymidine kinase) and UL22 (glycoprotein H) genes followed by five open reading frames (ORF) encoding putative proteins of 334 to 410 amino acids which exhibit no homology to any known herpesvirus protein. RNA analyses showed that these unique ILTV genes are indeed expressed. An origin of replication separates this cluster of unique genes from a conserved gene cluster consisting of the UL45, UL46, UL48, UL49, UL49.5, and UL50 homologs. The absence of UL47 from this position coincides with the localization of a UL47-homologous ORF within the unique short (U(S)) region of the ILTV genome (M. Wild, S. Cook, and M. Cochran, Virus Genes 12:107-116, 1996). Within the second analyzed region the ILTV UL21 homolog was found adjacent to the UL44 gene. We thus identified five novel herpesvirus genes in ILTV and present evidence for a large internal inversion in the ILTV U(L) regi...Continue Reading

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Citations

Feb 14, 2007·Veterinary Research·Walter FuchsThomas C Mettenleiter
Apr 20, 2011·BMC Genomics·Sang-Won LeeJoanne M Devlin
Dec 25, 2015·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Zhuanqiang YanYingzuo Bi
Dec 13, 2003·Journal of Virology·Barbara G KluppLynn W Enquist
Nov 27, 2009·The Journal of General Virology·Sophia P PavlovaWalter Fuchs
Dec 27, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Alireza MahmoudianGlenn F Browning

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