Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling

The Journal of Investigative Dermatology
Nishit R TrivediD M Thiboutot

Abstract

The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. Skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. Biopsies were also taken from normal skin of six subjects without acne. Gene array expression profiling was conducted using Affymetrix HG-U133A 2.0 arrays comparing lesional to nonlesional skin in acne patients and comparing nonlesional skin from acne patients to skin from normal subjects. Within the acne patients, 211 genes are upregulated in lesional skin compared to nonlesional skin. A significant proportion of these genes are involved in pathways that regulate inflammation and extracellular matrix remodeling, and they include matrix metalloproteinases 1 and 3, IL-8, human beta-defensin 4, and granzyme B. These data indicate a prominent role of matrix metalloproteinases, inflammatory cytokines, and antimicrobial peptides in acne lesions. These studies are the first describing the comprehe...Continue Reading

References

Aug 1, 1995·Journal of the American Academy of Dermatology·G F Webster
Nov 21, 2000·The Journal of Experimental Medicine·J A HeibeinR C Bleackley
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Mar 21, 2002·The British Journal of Dermatology·U JappeK T Holland
Oct 3, 2002·Nature Reviews. Immunology·Joseph A Trapani, Mark J Smyth
Jul 4, 2003·The Journal of Investigative Dermatology·Anthony H T JeremyWilliam J Cunliffe
Nov 24, 2004·Clinics in Dermatology·Mark D Farrar, Eileen Ingham
May 24, 2005·Nature Immunology·Michael E Selsted, Andre J Ouellette
Jun 29, 2005·The Journal of Investigative Dermatology·Marissa H BraffRichard L Gallo

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Citations

Aug 19, 2007·Nucleic Acids Research·Stefano CalzaYudi Pawitan
Dec 2, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vincent PetitSimon Wain-Hobson
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Chika IshikawaKiyofumi Yamanishi
Oct 5, 2010·Mediators of Inflammation·Daniela BraconiAnnalisa Santucci
Mar 5, 2008·The Journal of Clinical Investigation·Amanda M NelsonDiane M Thiboutot
Aug 26, 2014·PloS One·Hanna-Leena KelhäläAntti Lauerma
Jan 9, 2014·Nature Communications·Li HeYa-Ping Zhang
Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Po-Jung TsaiWen-Huey Wu
Jul 11, 2014·The Journal of Investigative Dermatology·Magdalena KistowskaLars E French
Aug 10, 2010·Microbes and Infection·Philippe A GrangeFrédéric Batteux
Apr 20, 2012·The Journal of Investigative Dermatology·Melanie C DispenzaDiane M Thiboutot
Jan 1, 2008·Advances in Dermatology·Kevin C Wang, Lee T Zane
Feb 20, 2009·The Journal of Investigative Dermatology·Bodo C MelnikChristos C Zouboulis
Apr 1, 2006·The Journal of Investigative Dermatology·Terry M SmithDiane M Thiboutot
Apr 1, 2006·The Journal of Investigative Dermatology·Amanda M NelsonDiane M Thiboutot
Jan 16, 2014·The Journal of Investigative Dermatology·Diane M ThiboutotE Anne Eady
Mar 29, 2014·Proteomics. Clinical Applications·Lars T Joeckel, Phillip I Bird
Oct 19, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·C C ZouboulisM Picardo
Aug 3, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·C BeylotB Dreno
Jan 1, 2015·Nature Reviews. Disease Primers·Sara Moradi TuchayiChristos C Zouboulis
Jun 11, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrenoUNKNOWN Global Alliance to Improve Outcomes in Acne
Jun 25, 2013·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Simona IanosiGabriel Ianosi
Apr 27, 2011·Dermato-endocrinology·Evgenia MakrantonakiChristos Zouboulis
Mar 13, 2010·Dermato-endocrinology·Amanda M NelsonDiane M Thiboutot
Mar 10, 2015·Dermatology and Therapy·Wen-Hwa LiMichael D Southall
Nov 5, 2016·International Journal of Dermatology·Seyma OzkanliNecmettin Akdeniz
Aug 4, 2016·Actas dermo-sifiliográficas·O M Moreno-Arrones, P Boixeda

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