Gene Association with Leprosy: A Review of Published Data

Frontiers in Immunology
Priscila Saamara MaziniPaulo Rodrigues-Santos

Abstract

Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge on the main hypothesis that genes are involved in the susceptibility for the disease in two distinct steps: for leprosy per se and in the development of the different clinical forms. These genes participate in the sensing, main metabolic pathway of immune response activation and, subsequently, on the evolution of the disease into its clinical forms. The aim of this review is to highlight the role of innate immune response in the context of leprosy, stressing their participation in the signaling and targeting processes in response to bacillus infection and on the evolution to the clinical forms of the disease.

References

Jan 1, 1990·Biotherapy·T Matsuda, T Hirano
Jun 10, 1982·Nature·E SkameneB A Taylor
Sep 1, 1996·Clinical Immunology and Immunopathology·H BurgmannW Graninger
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·N MizukiH Inoko
Jan 7, 1998·The Journal of Infectious Diseases·L AbelE Schurr
Dec 8, 1998·The Journal of Infectious Diseases·S RoyA V Hill
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L G BekkerG Kaplan
May 31, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R J AllcockP Price
Jan 17, 2002·The American Journal of Tropical Medicine and Hygiene·S J MeisnerA V Hill
Nov 26, 2002·The Journal of Infectious Diseases·Adalberto R SantosEuzenir N Sarno
Dec 18, 2002·Genes and Immunity·J FitnessA V S Hill
Jan 28, 2003·Journal of Molecular Biology·Andrew B WestMatthew J Farrer
Mar 22, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M P ReynardC V Navarrete
Apr 15, 2003·Nature Medicine·Stephan R KrutzikRobert L Modlin
Jan 23, 2004·Nature·Marcelo T MiraErwin Schurr
Mar 25, 2004·FEMS Immunology and Medical Microbiology·Eugenia PachecoMauricio A Arias
Feb 24, 2005·Human Genetics·Dheeraj MalhotraRamesh Bamezai
Mar 16, 2006·Pharmacogenetics and Genomics·Xiao Hui LiangDe Yun Wang
Aug 23, 2006·Human Molecular Genetics·Kerrie ToshRamasamy Pitchappan
Sep 13, 2006·FEMS Immunology and Medical Microbiology·Luiz Ricardo GoulartIsabela Maria Bernardes Goulart
Mar 14, 2007·Clinics in Dermatology·Stephen L Walker, Dina N J Lockwood
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher M JohnsonRichard I Tapping
Oct 9, 2007·The Journal of Infectious Diseases·Iara J de Messias-ReasonJurgen F J Kun
Nov 17, 2007·The Journal of Infectious Diseases·Adrian G Rosas-TaracoAlma Y Arce-Mendoza
Jan 8, 2008·The Journal of Infectious Diseases·Pierre-Yves BochudAlan Aderem
Feb 6, 2008·Human Genetics·Andrea AlterErwin Schurr
Feb 26, 2008·Nature Immunology·Jonathan C KaganRuslan Medzhitov
Sep 10, 2008·Tissue Antigens·D S A FranceschiJ E L Visentainer
Dec 9, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Danilo Santana Alessio FranceschiJeane Eliete Laguila Visentainer
Jan 28, 2009·Nature Reviews. Immunology·J Rodrigo MoraUlrich H von Andrian
Feb 28, 2009·International Immunology·Taro Kawai, Shizuo Akira
May 12, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P-Y BochudG Kaplan
May 22, 2009·The Journal of Infectious Diseases·Ron P SchuringLinda Oskam

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Citations

Sep 21, 2016·Small GTPases·Virtu Solano-ColladoStefania Spanò
Feb 24, 2018·Frontiers in Immunology·Carlos A M Silva, John T Belisle
Mar 10, 2017·Journal of Clinical Microbiology·Karina T O S JorgeFrederico M Soriani
Oct 17, 2017·JBI Database of Systematic Reviews and Implementation Reports·Silvana Margarida Benevides FerreiraCassia Baldini Soares
Feb 27, 2020·Seminars in Immunopathology·Katharina RöltgenCharlotte Avanzi
Oct 23, 2019·Frontiers in Immunology·Afonso Carrasco PepineliJeane Eliete Laguila Visentainer
Nov 6, 2020·International Journal of Immunogenetics·Luciana Ribeiro JarduliJeane Eliete Laguila Visentainer
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tiankai LiuWenhua Liu
May 1, 2018·American Journal of Human Genetics·Dong WangYong-Gang Yao

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