Gene-based antiangiogenic applications for corneal neovascularization

Survey of Ophthalmology
Siyin LiuColin E Willoughby

Abstract

Corneal avascularity is maintained by angiogenic privilege, an active process involving the production of higher level of angiostatic factors to offset the effect of angiogenic factors. A wide range of pathological insults to the cornea can disrupt this intricate equilibrium and promote angiogenesis and corneal neovascularization with resultant visual impairment. Corneal neovascularization is also a major risk factor for graft failure after keratoplasty. Current treatment options for corneal neovascularization are restricted by limited efficacy, adverse effects, and a short duration of action. The unique anatomical position and relative immune privilege of cornea make it an ideal tissue for gene-based therapies. Gene transfer vectors have been used to deliver or target genes involved in the pathogenesis of corneal neovascularization in animal models. Several proangiogenic and antiangiogenic factors have been targeted and assessed in experimentally induced corneal neovascularization. Antisense oligonucleotides targeting corneal neovascularization have entered human clinical trials and have not required vector delivery systems. The emergence of these RNA-based strategies heralds a new era in the management of corneal neovasculari...Continue Reading

Citations

Oct 4, 2018·Translational Vision Science & Technology·Christoph PalmeBernhard Steger
Dec 14, 2018·Current Gene Therapy·Xiao-Xiao Lu, Shao-Zhen Zhao
Apr 20, 2019·Chemical Biology & Drug Design·Jiahao ZhangYan Zhang
Mar 24, 2020·Nucleic Acid Therapeutics·Viet Q ChauV Vinod Mootha
Apr 21, 2019·Nanomaterials·Josune TorrecillaAlicia Rodríguez-Gascón
Aug 20, 2020·Acta Biomaterialia·Lokendrakumar C BenganiJoseph B Ciolino
Nov 18, 2020·Experimental Eye Research·Shibani SupeKavita Singh
Nov 23, 2020·Experimental Eye Research·Matthew P Nicholas, Naveen Mysore
May 17, 2021·Survey of Ophthalmology·Vito RomanoStephen B Kaye
Sep 9, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jian PanZipei Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Related Papers

Ophthalmology
Surekha MaddulaBalamurali K Ambati
Progress in Retinal and Eye Research
Rajiv R MohanAshish Tandon
The Ocular Surface
Andrew J W HuangEleut Hernandez
Advances in Experimental Medicine and Biology
Xue CaiJames F McGinnis
© 2022 Meta ULC. All rights reserved