Gene-based mapping and pathway analysis of metabolic traits in dairy cows

PloS One
Ngoc-Thuy HaHenner Simianer

Abstract

The metabolic adaptation of dairy cows during the transition period has been studied intensively in the last decades. However, until now, only few studies have paid attention to the genetic aspects of this process. Here, we present the results of a gene-based mapping and pathway analysis with the measurements of three key metabolites, (1) non-esterified fatty acids (NEFA), (2) beta-hydroxybutyrate (BHBA) and (3) glucose, characterizing the metabolic adaptability of dairy cows before and after calving. In contrast to the conventional single-marker approach, we identify 99 significant and biologically sensible genes associated with at least one of the considered phenotypes and thus giving evidence for a genetic basis of the metabolic adaptability. Moreover, our results strongly suggest three pathways involved in the metabolism of steroids and lipids are potential candidates for the adaptive regulation of dairy cows in their early lactation. From our perspective, a closer investigation of our findings will lead to a step forward in understanding the variability in the metabolic adaptability of dairy cows in their early lactation.

References

Apr 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·T H Herdt, J C Smith
Jul 24, 2004·American Journal of Human Genetics·Benjamin M Neale, Pak C Sham
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Apr 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·P A Marks, J Banks
Dec 30, 2006·PLoS Genetics·Nick PattersonDavid Reich
Feb 5, 2009·BMC Bioinformatics·Marit Ackermann, Korbinian Strimmer
Feb 10, 2009·American Journal of Human Genetics·Brian L Browning, Sharon R Browning
Jul 9, 2009·European Journal of Human Genetics : EJHG·Gang PengMomiao Xiong
Jul 6, 2010·American Journal of Human Genetics·Jimmy Z LiuStuart Macgregor
Jan 20, 2011·Journal of Animal Physiology and Animal Nutrition·M GraberH A van Dorland
Feb 15, 2011·Comparative Immunology, Microbiology and Infectious Diseases·G Andres Contreras, Lorraine M Sordillo
Mar 15, 2011·American Journal of Human Genetics·Miao-Xin LiPak C Sham
Aug 11, 2011·PLoS Genetics·Hailiang HuangDan E Arking
Sep 9, 2011·Briefings in Bioinformatics·Jui-Hung HungCharles DeLisi
Nov 15, 2011·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Nov 17, 2011·Nucleic Acids Research·Paul FlicekStephen M J Searle
Dec 4, 2012·Nucleic Acids Research·Paul FlicekStephen M J Searle
Dec 3, 2013·Current Genomics·Guolian KangYuehua Cui
Dec 11, 2013·Statistics in Medicine·Saskia Freytag, Heike Bickeböller

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Citations

Oct 8, 2019·Journal of Dairy Science·T D W LukeJ E Pryce
Aug 27, 2019·Journal of Dairy Science·Angela CostaMauro Penasa
May 14, 2017·G3 : Genes - Genomes - Genetics·Jordi Leno-ColoradoMiguel Pérez-Enciso
Dec 7, 2019·Animals : an Open Access Journal From MDPI·Francisco A Leal YepesHeather J Huson

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Methods Mentioned

BETA
SMA
PCA

Software Mentioned

Ensembl
WRST
GBST
GBST GSEA )
BEAGLE
WKST
GSEA

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