Gene-by-social-environment interaction (GxSE) between ADCYAP1R1 genotype and neighborhood crime predicts major depression symptoms in trauma-exposed women

Journal of Affective Disorders
Sarah R LoweKarestan C Koenen

Abstract

Few studies have explored interactions between genes and social environmental exposures (GxSEs) for trauma-related psychopathology, including symptoms of posttraumatic stress (PTS) and major depression (MD). The extant literature suggests the possibility of a GxSE between the rs2267735 variant of the ADCYAP1R1 gene and neighborhood crime. The current study aimed to explore this possibility among a predominantly African American sample of trauma-exposed women. Female participants (N=1361) were recruited from a public hospital, and completed measures of PTS and MD symptoms and provided DNA samples. Participants' home addresses were mapped onto 300 neighborhoods (2010 census tracts), and data on crime within neighborhoods was collected. Multilevel models detected a significant GxSE between rs2267735 and neighborhood crime for MD symptoms (p=.01). Having two copies of the risk (C) allele was associated with higher MD symptoms for participants living in high-crime neighborhoods. At least six limitations are noteworthy: (1) low statistical power; (2) use of self-report symptom inventories; (3) lack of information on symptom onset; (4) homogeneous sample from a single metropolitan area; (5) non-specific index of crime; and (6) use of ...Continue Reading

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Citations

Jul 27, 2017·Journal of Traumatic Stress·Mackenzie J LindNicole R Nugent
Oct 5, 2017·British Journal of Pharmacology·Tahlia Sundrum, Christopher S Walker
Sep 18, 2018·Genes, Brain, and Behavior·Jennifer S Stevens, Tanja Jovanovic
Jan 8, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel A RossNaomi M Simon
Jun 27, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tanja JovanovicKerry J Ressler
Jan 26, 2021·Anxiety, Stress, and Coping·Jacqueline Samantha WomersleySian Megan Joanna Hemmings

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