PMID: 16629162Apr 25, 2006Paper

Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum.

Biological Research
James F Collins

Abstract

Previous studies revealed novel genetic changes in the duodenal mucosa of iron-deprived rats during postnatal development. These observations are now extended to compare the genetic response to iron deficiency in the duodenum versus jejunum of 12-wk-old rats. cRNA samples were prepared from the duodenal and jejunal mucosa of three groups each of control and iron-deficient rats and hybridized with RAE 230A and 230B gene chips (Affymetrix). Stringent data reduction strategies were employed. Results showed that several genes were similarly induced in both gut segments, including DMT1, Dcytb, transferrin receptor 1, heme oxygenase 1, metallothionein, the Menkes copper ATPase (ATP7A), tripartitie motif protein 27, and the sodium-dependent vitamin C transporter. However, a subset of genes showed regulation in only one or the other gut segment. In duodenum only, gastrokine 1, trefoil factor 1 and claudin 2 were induced by iron-deficiency. Other genes previously identified were only regulated in the duodenum. Overall, these studies demonstrate similarities and distinct differences in the genetic response to iron deprivation in the duodenum versus jejunum and provide evidence that more distal gut segments also may play a role in increas...Continue Reading

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Citations

Jun 27, 2007·Journal of Molecular Evolution·Laura Marie Camus, Lisa A Lambert
Nov 18, 2010·Development Genes and Evolution·Cunshuan XuFuchun Zhang
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Perungavur N RanganathanJames F Collins
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