Gene co-expression network analysis identifies the hub genes associated with immune functions for nocturnal hemodialysis in patients with end-stage renal disease

Medicine
Hongwei DaiBo Zhu

Abstract

End-stage renal disease (ESRD) is the final stage of chronic kidney disease in which the kidney is not sufficient to meet the needs of daily life. It is necessary to understand the role of genes expression involved in ESRD patient responses to nocturnal hemodialysis (NHD) and to improve the immunity responsiveness. The aim of this study was to investigate novel immune-associated genes that may play important roles in patients with ESRD.The microarray expression profiles of peripheral blood in patients with ESRD before and after NHD were analyzed by network-based approaches, and then using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway analysis to explore the biological process and molecular functions of differentially expressed genes. Subsequently, a transcriptional regulatory network of the core genes and the connected transcriptional regulators was constructed. We found that NHD had a significant effect on neutrophil activation and immune response in patients with ESRD.In addition, Our findings suggest that MAPKAPK3, RHOA, ARRB2, FLOT1, MYH9, PRKCD, RHOG, PTPN6, MAPK3, CNPY3, PI3KCG, and PYGL genes maybe potential targets regulated by core transcriptional factors, including ARNT, C/EBPalpha, CEBPA, CRE...Continue Reading

References

Nov 1, 1973·The American Journal of Clinical Nutrition·A SanchezU D Register
Jan 1, 1980·The American Journal of Medicine·O T AndrewM H Humphreys
Dec 10, 1998·Nucleic Acids Research·H OgataM Kanehisa
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J S Cameron
Jul 5, 2002·American Journal of Nephrology·Susan K Fellner, Mabel L Purkerson
Aug 26, 2003·Journal of the American Society of Nephrology : JASN·Fayez Al-HejailiRobert M Lindsay
Oct 6, 2005·Current Opinion in Nephrology and Hypertension·Darren Yuen, Christopher T Chan
Jun 30, 2006·Journal of Neurochemistry·Angel BarcoEric R Kandel
Sep 6, 2007·Genome Research·Sorin DraghiciRoberto Romero
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Bruce F CulletonBraden J Manns
Sep 29, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jean EthierEric W Young
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Christopher T ChanHans A Messner
Dec 19, 2008·Journal of the American Society of Nephrology : JASN·Holger ReineckeGünter Breithardt
Dec 26, 2008·Kidney International·Braden J MannsUNKNOWN Alberta Kidney Disease Network
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Kevin E ChanRaymond M Hakim
Apr 3, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Ann BugejaMarc Goldstein
Apr 25, 2009·Nature Reviews. Immunology·Michael J Hickey, Paul Kubes
Nov 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andy Y WenLloyd S Miller
Jan 22, 2011·Current Opinion in Nephrology and Hypertension·Philip A McFarlane
Jul 9, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Masakazu OkawaTooru Inoue
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

❮ Previous
Next ❯

Citations

Dec 29, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ting LuoYong Dai
Jun 18, 2019·Frontline Gastroenterology·Stefania Chetcuti ZammitReena Sidhu
Aug 22, 2018·Postgraduate Medical Journal·Shing Fung LeeFrank Chi Sing Wong

❮ Previous
Next ❯

Methods Mentioned

BETA
chip
RNA-Seq

Software Mentioned

DESseq2
DESeq2
deepSplit
Bioconductor
R
WGCNA
Volcano

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.