Gene coexpression patterns predict opiate-induced brain-state transitions

Proceedings of the National Academy of Sciences of the United States of America
Julia K BrynildsenJulie A Blendy

Abstract

Opioid addiction is a chronic, relapsing disorder associated with persistent changes in brain plasticity. Reconfiguration of neuronal connectivity may explain heightened abuse liability in individuals with a history of chronic drug exposure. To characterize network-level changes in neuronal activity induced by chronic opiate exposure, we compared FOS expression in mice that are morphine-naïve, morphine-dependent, or have undergone 4 wk of withdrawal from chronic morphine exposure, relative to saline-exposed controls. Pairwise interregional correlations in FOS expression data were used to construct network models that reveal a persistent reduction in connectivity strength following opiate dependence. Further, we demonstrate that basal gene expression patterns are predictive of changes in FOS correlation networks in the morphine-dependent state. Finally, we determine that regions of the hippocampus, striatum, and midbrain are most influential in driving transitions between opiate-naïve and opiate-dependent brain states using a control theoretic approach. This study provides a framework for predicting the influence of specific therapeutic interventions on the state of the opiate-dependent brain.

References

Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Sep 13, 2002·The New England Journal of Medicine·David Goldman, Christina S Barr
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Nov 8, 2002·Current Molecular Medicine·Danny G WinderRobert T Matthews
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Glenda C Harris, Gary Aston-Jones
Mar 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·A BarratA Vespignani
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
May 13, 2011·Nature·Yang-Yu LiuAlbert-László Barabási
Feb 22, 2012·NeuroImage·Andrew ZaleskyEd Bullmore
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Dec 15, 2012·Pharmacological Reports : PR·Barbara ZiółkowskaRyszard Przewłocki
Apr 4, 2014·Nature·Seung Wook OhHongkui Zeng
Jun 28, 2015·Neuroscience·L M YagerS M Ferguson
Oct 2, 2015·Nature Communications·Shi GuDanielle S Bassett
Oct 3, 2015·Chaos·Adilson E Motter
Jan 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ben D Fulcher, Alex Fornito
May 18, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Elizabeth A CabreraGene-Jack Wang
Jul 30, 2016·Scientific Reports·Richard F BetzelDanielle S Bassett
Aug 28, 2016·Biological Psychiatry·Ying ShenTi-Fei Yuan
Sep 10, 2016·PLoS Computational Biology·Sarah Feldt MuldoonDanielle S Bassett
Jan 16, 2017·NeuroImage·Shi GuDanielle S Bassett
Feb 24, 2017·Nature Neuroscience·Danielle S Bassett, Olaf Sporns
Apr 22, 2017·Frontiers in Human Neuroscience·Hada Fong-Ha Ieong, Zhen Yuan
Aug 5, 2017·ACS Chemical Neuroscience·Ludovic D Langlois, Fereshteh S Nugent
Apr 21, 2018·Neural Plasticity·Dawn E MuskiewiczF Scott Hall
Jul 14, 2018·Nature Reviews. Neuroscience·Danielle S BassettJoshua I Gold
Oct 5, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hestia MoningkaSarah W Yip
Nov 23, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Matthew Hearing
Mar 23, 2019·Frontiers in Psychiatry·Jennifer L StewartJerzy Bodurka
Jan 23, 2020·Journal of Neural Engineering·Teresa M KarrerDanielle S Bassett

❮ Previous
Next ❯

Citations

Oct 23, 2020·Journal of Neuroscience Methods·J R BourgeoisA M Kopec

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
R
Fiji
Ingenuity Pathway Analysis (
Ingenuity Pathway Analysis
corrplot
Allen Mouse Brain Connectivity Atlas
igraph

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Cold Spring Harbor Symposia on Quantitative Biology
I M VermaP Sassone-Corsi
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
K N GracyG F Koob
© 2021 Meta ULC. All rights reserved