Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling

American Journal of Physiology. Heart and Circulatory Physiology
Hua ZhangJ E Faber

Abstract

In vitro studies have shown that stimulation of alpha1-adrenoceptors (ARs) directly induces proliferation, hypertrophy, and migration of arterial smooth muscle cells and adventitial fibroblasts. In vivo studies confirmed these findings and showed that catecholamine trophic activity becomes excessive after experimental balloon injury and contributes to neointimal growth, adventitial thickening, and lumen loss. However, past studies have been limited by selectivity of pharmacological agents. The aim of this study, in which mice devoid of norepinephrine and epinephrine synthesis [dopamine beta-hydroxylase (DBH-/-)] or deficient in alpha1-AR subtypes expressed in murine carotid (alpha1B-AR-/- and alpha1D-AR-/-) were used, was to test the hypothesis that catecholamines contribute to wall hypertrophy after injury. At 3 wk after injury of wild-type mice, lumen area and carotid circumference increased significantly, and hypertrophy of media and adventitia was in excess of that needed to restore circumferential wall stress to normal. In DBH-/- and alpha1B-AR-/- mice, increases in lumen area, circumference, and hypertrophy of the media and adventitia were reduced by 50-91%, resulting in restoration of wall tension to nearly normal (DBH-/...Continue Reading

References

Dec 1, 1992·The British Journal of Surgery·R VashishtM K O'Malley
Sep 1, 1989·The British Journal of Surgery·M K O'MalleyN J O'Higgins
Feb 1, 1994·Circulation·R C CandipanJ P Cooke
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·A CavalliS Cotecchia
Dec 16, 1998·European Journal of Pharmacology·J R Docherty
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·R C AlanizC B Wilson
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F A DinennoH Tanaka
Sep 7, 2000·Circulation·M R WardC Borst
Oct 20, 2001·Hypertension·C CantiniI Lartaud-Idjouadiene
Jan 24, 2002·Circulation·Allen P BurkeRenu Virmani
Feb 28, 2002·Circulation·Amanda M VarnavaMichael J Davies
Apr 10, 2002·Circulation·Carmine VecchioneGiuseppe Lembo
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Hua ZhangJames E Faber
Jun 18, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Xiaosong Wang, Beverly Paigen
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·D Gregg Rokosh, Paul C Simpson
Jul 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Chris J Sullivan, James B Hoying
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Cauveh EramiJames E Faber
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·John C TeetersJames E Faber

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Citations

Sep 8, 2007·European Journal of Pediatrics·Hendrika KnoesterAlbert P Bos
Feb 21, 2006·Clinical and Experimental Pharmacology & Physiology·James E Faber, Nengyu Yang
Oct 18, 2005·Acta Pharmacologica Sinica·Zhong-jian Chen, Kenneth P Minneman
Sep 27, 2018·American Journal of Physiology. Cell Physiology·Aytan MusayevaAdrian Gericke
Nov 14, 2006·British Journal of Pharmacology·J T LilesP J Kadowitz
Apr 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Cauveh EramiJames E Faber
Jun 27, 2006·American Journal of Physiology. Heart and Circulatory Physiology·James E FaberHua Zhang
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·James E FaberHua Zhang
Mar 27, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Chihiro HosodaAkito Tanoue
Sep 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Debanjan ChakrobortyChandrani Sarkar
Sep 3, 2017·Cardiovascular Research·Elliott GoldbergGiovanni Ferrari
Apr 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dan ChalothornJames E Faber
Apr 14, 2006·The Journal of Trauma·Ankush GosainLuisa A DiPietro
Nov 10, 2015·Genes, Brain, and Behavior·G B Bissonette, M R Roesch
Aug 15, 2019·Human Molecular Genetics·Claudia P CabreraMark J Caulfield
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey

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