Gene discovery in the auditory system using a tissue specific approach

American Journal of Medical Genetics. Part a
Cynthia C Morton

Abstract

Molecular methods applied to the study of hereditary hearing loss in the past decade have revealed a copious number of genes representing a great diversity of cellular functions. In some instances, identification of these genes involved in deafness disorders has provided the portal to investigations of pathways not previously envisioned to underlie human hearing. Sequence analysis of a human fetal cochlear cDNA library has been employed to generate thousands of ESTs (expressed sequence tags) that provide a transcript map of the human cochlea and are a resource of candidate genes for positional cloning endeavors.

References

May 17, 2002·Human Molecular Genetics·Cynthia C Morton
Jun 27, 2002·Journal of the Association for Research in Otolaryngology : JARO·Barbara L ResendesCynthia C Morton
Oct 17, 2002·Journal of Neurobiology·Zheng-Yi Chen, David P Corey

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Citations

May 19, 2006·Expert Review of Molecular Diagnostics·Iris Schrijver, Phyllis Gardner
Nov 21, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Angela M Meyer zum GottesbergeWolfgang F Vogel

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