PMID: 11287226Apr 5, 2001Paper

Gene discovery via metabolic profiling

Current Opinion in Biotechnology
R N Trethewey

Abstract

Biochemical analysis is adding a new dimension to the process of gene discovery. Two major developments have recently taken place in the emerging science of biochemical genomics. The first is an approach that uses a combination of tagged fusion proteins and simple pooling strategies in order to efficiently and directly assign biochemical function to the products of open reading frames (ORFs) expressed in yeast. The second is the application of metabolic profiling technologies to the study of mutant and transgenic plants. The latter approach has the potential not only to discover novel genes but also to ascribe a function to them in the context of the organism from which they are derived.

References

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Citations

Feb 19, 2003·Phytochemistry·Lloyd W SumnerRichard A Dixon
Dec 10, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Gary H ThorgaardYniv Palti
Nov 2, 2013·Nature Protocols·Vera MugoniMassimo M Santoro
Sep 22, 2007·Omics : a Journal of Integrative Biology·Silas Granato Villas-Bôas, Per Bruheim
Jun 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Goutham N Vemuri, Aristos A Aristidou
Sep 25, 2003·Annual Review of Plant Biology·Wolfram Weckwerth
Jun 10, 2004·Genome Biology·Joachim KopkaMark Stitt
Sep 25, 2004·Mass Spectrometry Reviews·Silas G Villas-BôasJens Nielsen
Jul 19, 2006·Cellular & Molecular Biology Letters·Holger Hesse, Rainer Hoefgen
Feb 6, 2004·Journal of Biochemistry and Molecular Biology·Juan I Castrillo, Stephen G Oliver
Jan 22, 2002·Metabolic Engineering·Denis RonteinAndrew D Hanson
Jan 22, 2002·Metabolic Engineering·John A Morgan, David Rhodes
Jul 17, 2004·Metabolic Engineering·Christoffer Bro, Jens Nielsen
Jun 19, 2007·Poultry Science·R L WalzemL A Cogburn
Dec 1, 2006·Analytical Chemistry·Danielle Ryan, Kevin Robards
Apr 17, 2003·Journal of Agricultural and Food Chemistry·Travis S WalkerJorge M Vivanco

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