Gene drive systems: do they have a place in agricultural weed management?

Pest Management Science
Paul Neve

Abstract

There is a pressing need for novel control techniques in agricultural weed management. Direct genetic control of agricultural pests encompasses a range of techniques to introduce and spread novel, fitness-reducing genetic modifications through pest populations. Recently, the development of CRISPR-Cas9 gene editing has brought these approaches into sharper focus. Proof of concept for CRISPR-Cas9-based gene drives has been demonstrated for the control of disease-vectoring insects. This article considers whether and how gene drives may be applied in agricultural weed management, focusing on CRISPR-Cas9-based systems. Population-suppression drives might be employed to introduce and proliferate deleterious mutations that directly impact fitness and weediness, whereas population-sensitizing drives would seek to edit weed genomes so that populations are rendered more sensitive to subsequent management interventions. Technical challenges relating to plant transformation and gene editing in planta are considered, and the implementation of gene drives for timely and sustainable weed management is reviewed in the light of weed population biology. The technical, biological, practical and regulatory challenges remain significant. Modelling-...Continue Reading

References

Apr 3, 1992·Science·R W BeemanR E Denell
Jan 1, 1994·Journal of Medical Entomology·J M Ribeiro, M G Kidwell
Dec 21, 2004·Journal of Medical Entomology·Akio MoriDavid W Severson
Apr 15, 2006·Science·Saeko KonishiMasahiro Yano
Jan 2, 2007·Pest Management Science·Regina G Belz
Feb 27, 2007·Nature Biotechnology·Guoliang FuLuke Alphey
Nov 15, 2007·Evolution; International Journal of Organic Evolution·Fred Gould
Mar 3, 2010·Annual Review of Plant Biology·Stephen B Powles, Qin Yu
Jan 5, 2013·Science·Le CongFeng Zhang
Jan 5, 2013·Science·Prashant MaliGeorge M Church
Jul 9, 2013·Trends in Genetics : TIG·Christophe DélyeValérie Le Corre
Dec 18, 2013·Science·Ophir ShalemFeng Zhang
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Austin Burt
Jul 19, 2014·Science·Kenneth A OyeJames P Collins
Jan 18, 2015·Advances in Applied Microbiology·John A LucasBart A Fraaije
Aug 1, 2015·Science·Omar S AkbariJill Wildonger
Aug 2, 2015·Genetics·Robert L UncklessAndrew G Clark
Aug 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bruce L WebberOwain R Edwards
Nov 17, 2015·Nature Biotechnology·James E DiCarloGeorge M Church
Feb 16, 2016·Nature Reviews. Genetics·Jackson ChamperOmar S Akbari
Apr 19, 2016·Evolutionary Applications·Philip T LeftwichTracey Chapman
Dec 13, 2016·Genetics·Robert L UncklessPhilipp W Messer
Dec 26, 2016·Evolution, Medicine, and Public Health·James J Bull
Jul 21, 2017·PLoS Genetics·James J Bull, Harmit S Malik
Aug 9, 2017·EMBO Reports·Virginie Courtier-OrgogozoChristophe Boëte
Aug 9, 2017·Nature Biotechnology·Zach AdelmanChris Wozniak
Sep 13, 2017·BMC Biology·H Charles J GodfrayAustin Burt
Dec 2, 2017·Pest Management Science·Michael J WalshMuthukumar V Bagavathiannan
Apr 25, 2018·Pest Management Science·Karl RavetTodd A Gaines

❮ Previous
Next ❯

Citations

Sep 26, 2019·Proceedings. Biological Sciences·Luke G BarrettDonald M Gardiner
Jun 2, 2020·ELife·Luke KempWilliam J Sutherland
Aug 5, 2020·The American Journal of Tropical Medicine and Hygiene·Adam KelseyRebeca Carballar-Lejarazú
Aug 21, 2020·Pest Management Science·Patrick J Tranel
Sep 25, 2019·Plants·Sara L MartinTracey James
Apr 5, 2020·Plants·Hugh J Beckie
Mar 2, 2019·Annual Review of Plant Biology·Joachim SchiemannThorben Sprink
May 28, 2020·Frontiers in Plant Science·Feng-Yan ZhouYun-Jing Han
Feb 11, 2020·Frontiers in Bioengineering and Biotechnology·Heidi J Mitchell, Detlef Bartsch
Dec 19, 2019·Plants·Eric L PattersonTodd A Gaines
Nov 30, 2019·Plant Science : an International Journal of Experimental Plant Biology·Valeria E PerottiHugo R Permingeat
Feb 6, 2021·Biomolecular Concepts·Joel C Eissenberg
Mar 10, 2021·BMC Medical Ethics·N de GraeffAnnelien L Bredenoord
Jul 6, 2021·AJOB Empirical Bioethics·N de GraeffAnnelien L Bredenoord
Jul 10, 2021·Trends in Plant Science·Gourav SharmaDavid C Haak
Dec 30, 2021·Health Security·Justin Overcash, Andrew Golnar

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
genetic modifications

Related Concepts

Related Feeds

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR for Genome Editing

Genome editing technologies enable the editing of genes to create or correct mutations. Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). Here is the latest research on the use of CRISPR-Cas system in gene editing.