Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans.

Scientific Reports
Karin Brigit HolthausLeopold Eckhart

Abstract

Major protein components of the mammalian skin barrier are encoded by genes clustered in the Epidermal Differentiation Complex (EDC). The skin of cetaceans, i.e. whales, porpoises and dolphins, differs histologically from that of terrestrial mammals. However, the genetic regulation of their epidermal barrier is only incompletely known. Here, we investigated the EDC of cetaceans by comparative genomics. We found that important epidermal cornification proteins, such as loricrin and involucrin are conserved and subtypes of small proline-rich proteins (SPRRs) are even expanded in numbers in cetaceans. By contrast, keratinocyte proline rich protein (KPRP), skin-specific protein 32 (XP32) and late-cornified envelope (LCE) genes with the notable exception of LCE7A have been lost in cetaceans. Genes encoding proline rich 9 (PRR9) and late cornified envelope like proline rich 1 (LELP1) have degenerated in subgroups of cetaceans. These data suggest that the evolution of an aquatic lifestyle was accompanied by amplification of SPRR genes and loss of specific other epidermal differentiation genes in the phylogenetic lineage leading to cetaceans.

References

Feb 1, 1990·The Journal of Investigative Dermatology·J KubilusH P Baden
Nov 25, 1988·Nucleic Acids Research·F Corpet
Apr 25, 2002·Nature Reviews. Genetics·Elaine Fuchs, Srikala Raghavan
Sep 2, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Lorenzo Alibardi
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Eleonora CandiGerry Melino
Apr 28, 2005·The Journal of Investigative Dermatology·Benjamin JacksonCarolyn Byrne
Dec 6, 2005·Genomics·Sabrina K HawthorneKenneth C Kleene
Dec 2, 2008·Experimental Dermatology·Ehrhardt ProkschJens-Michael Jensen
Jan 21, 2011·The Journal of Investigative Dermatology·Wilbert P VermeijClaude Backendorf
Aug 24, 2011·Nature Reviews. Molecular Cell Biology·Cory L SimpsonKathleen J Green
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Julie HenryMichel Simon
Jun 5, 2012·Nucleic Acids Research·Panu ArtimoHeinz Stockinger
Nov 26, 2013·Nature Genetics·Hyung-Soon YimJung-Hyun Lee
May 6, 2014·Trends in Ecology & Evolution·Michael R McGowenDerek E Wildman
Aug 30, 2014·Molecular Biology and Evolution·Bettina StrasserLeopold Eckhart
Oct 8, 2014·BMC Genomics·Mariana F NeryJuan C Opazo
Mar 6, 2015·Experimental Dermatology·Bettina StrasserLeopold Eckhart
Mar 31, 2015·International Immunology·Takeshi Matsui, Masayuki Amagai
Nov 26, 2015·Molecular Biology and Evolution·Karin Brigit HolthausLeopold Eckhart
May 12, 2016·The Journal of Investigative Dermatology·Yosuke IshitsukaDennis R Roop
Apr 8, 2017·Molecular Biology and Evolution·Sudhir KumarS Blair Hedges
Apr 17, 2017·The Journal of Investigative Dermatology·Inez Y Oh, Cristina de Guzman Strong
Jun 7, 2017·Current Biology : CB·Nicholas D Pyenson
Jun 22, 2017·The Journal of Investigative Dermatology·Hanna NiehuesJoost Schalkwijk
Jul 13, 2018·Immunogenetics·Mónica Lopes-MarquesL Filipe C Castro
Jul 19, 2018·Experimental Dermatology·Mariko Yokouchi, Akiharu Kubo
Nov 6, 2018·Scientific Reports·Ulrich GerstelJens-Michael Schröder
Dec 6, 2018·Molecular Biology and Evolution·Florian EhrlichLeopold Eckhart
May 3, 2019·Immunogenetics·Mónica Lopes-MarquesL Filipe C Castro
Jul 20, 2019·Evolutionary Bioinformatics Online·Leopold EckhartErwin Tschachler
Jun 10, 2020·Integrative and Comparative Biology·Emily K LamJosé Pablo Vázquez-Medina
Oct 23, 2020·Molecular Ecology Resources·Phillip A MorinErich D Jarvis

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Software Mentioned

Basic Local Alignment Search Tool ( BLAST )
ProtParam
ENSEMBL
MultAlin
tBLASTn

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