PMID: 6105560Sep 6, 1980Paper

Gene enrichment in an American Indian population: an excess of severe combined immunodeficiency disease

Lancet
S MurphyT Coons

Abstract

A subgroup of Athabascan Indians in Arizona and New Mexico was found to have an unusually high incidence of severe combined immunodeficiency, probably due to founder effect. Closed genetic pressures have limited their histocompatibility-antigen heterogeneity, enabling 3 patients to be grafted, 2 of them across HLA-B locus barriers.

References

Jan 1, 1976·Scandinavian Journal of Immunology·B HanebergA Dalen
Oct 15, 1977·Lancet·A Comfort
Mar 1, 1979·The Journal of Pediatrics·W R JarvisE W Gelfand
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E A Thompson, J V Neel
Mar 1, 1976·American Journal of Physical Anthropology·P L WorkmanH R Nevanlinna
Dec 14, 1968·Nature·D F Roberts
Apr 4, 1969·Science·C M Woolf, F C Dukepoo
Feb 1, 1980·Transplantation·W A SterlingD Megill

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Citations

Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N S Magnuson, L E Perryman
Jun 21, 2011·PloS One·Alice Tagliani-RibeiroLavinia Schuler-Faccini
Jul 10, 2004·Immunological Reviews·Françoise Le DeistJean-Pierre de Villartay
Sep 10, 2016·Human Gene Therapy·Divya PunwaniMorton J Cowan
Oct 1, 1991·DICP : the Annals of Pharmacotherapy·C R LeeR Whaley
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lanying LiMorton J Cowan
Sep 6, 2021·Clinical Obstetrics and Gynecology·Anne H Mardy, Mary E Norton

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