Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures.

Human Genomics
Hortensia Moreno-MaciasN M Laird

Abstract

Longitudinal studies are an important tool for analysing traits that change over time, depending on individual characteristics and environmental exposures. Complex quantitative traits, such as lung function, may change over time and appear to depend on genetic and environmental factors, as well as on potential gene-environment interactions. There is a growing interest in modelling both marginal genetic effects and gene-environment interactions. In an admixed population, the use of traditional statistical models may fail to adjust for confounding by ethnicity, leading to bias in the genetic effect estimates. A variety of methods have been developed to account for the genetic substructure of human populations. Family-based designs provide an important resource for avoiding confounding due to admixture. To date, however, most genetic analyses have been applied to cross-sectional designs. In this paper, we propose a methodology which aims to improve the assessment of main genetic effect and gene-environment interaction effects by combining the advantages of both longitudinal studies for continuous phenotypes, and the family-based designs. This approach is based on an extension of ordinary linear mixed models for quantitative phenot...Continue Reading

References

Jul 1, 1969·Annals of Human Genetics·C C Li
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Oct 31, 2000·Genetic Epidemiology·N M LairdX Xu
Nov 25, 2003·Genetic Epidemiology·W James GaudermanShelley Bull
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Apr 19, 2006·Nature Reviews. Genetics·Nan M Laird, Christoph Lange
Jul 4, 2007·Proceedings of the American Thoracic Society·Fernando D Martinez
Jul 4, 2007·Proceedings of the American Thoracic Society·Shweta ChoudhryEsteban González Burchard
Oct 15, 2008·Human Molecular Genetics·Chao TianMichael F Seldin
Nov 5, 2008·Annual Review of Public Health·Stephanie J London, Isabelle Romieu

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