Gene-environment interactions in asthma

The Journal of Allergy and Clinical Immunology
E Von Mutius

Abstract

Asthma is a complex disease, and its incidence is determined by an intricate interplay of genetic and environmental factors. The identification of novel genes for asthma suggests that many genes with small effects rather than few genes with strong effects contribute to the development of asthma. These genetic effects may in part differ with respect to a subject's environmental exposures, although some genes may also exert their effect independently of the environment. Whereas the geneticist uses highly advanced, rapid, comprehensive technologies to assess even subtle changes in the human genome, the researcher interested in environmental exposures is often confronted with crude information obtained from questionnaires or interviews. There is thus substantial need to develop better tools for individual exposure assessment in all relevant environmental fields. Despite these limitations, a number of important gene-environment interactions have been identified. These interactions point to the biology of environmental exposures as the involved genetic variation is suggestive of certain underlying mechanisms. Furthermore, the identification of subjects who are particularly susceptible to environmental hazards through genetic analyses...Continue Reading

References

Dec 2, 1975·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·P D Caligari, K Mather
Oct 1, 1986·Biochimica Et Biophysica Acta·A A FryerR C Strange
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·Z WangX Xu
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·E BergamaschiA Mutti
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·R W AtkinsonK Katsouyanni
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandJohn M Peters
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Frank D GillilandLouis Dubeau
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Jan 22, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J KarjalainenM Hurme
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Susan ColillaUNKNOWN Collaborative Study for the Genetics of Asthma
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Monika WernerJoachim Heinrich
Sep 13, 2003·American Journal of Respiratory and Critical Care Medicine·Gloria L DavidStephanie J London
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·James E GernRobert F Lemanske
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Waltraud EderUNKNOWN ALEX Study Team
May 8, 2004·The Journal of Allergy and Clinical Immunology·Robert Theodoor van StrienUNKNOWN ALEX Study Team
May 12, 2004·Paediatric Respiratory Reviews·Donald Payne, Andrew Bush
May 27, 2004·American Journal of Respiratory and Critical Care Medicine·Richard W Atkinson, UNKNOWN APHEA 2 Project
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Thorsten Kurz, Carole Ober
Oct 16, 2004·American Journal of Respiratory and Critical Care Medicine·Ian A YangStephen T Holgate
Feb 24, 2005·American Journal of Human Genetics·Sabine HoffjanCarole Ober
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Shweta ChoudhryEsteban González Burchard
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Deborah A MeyersEugene R Bleecker
Aug 20, 2005·American Journal of Respiratory and Critical Care Medicine·Wayne J MorganFernando D Martinez
Dec 17, 2005·Current Opinion in Pulmonary Medicine·Augusto A Litonjua
Jan 6, 2006·Genes and Immunity·C Ober, S Hoffjan
Apr 15, 2006·American Journal of Respiratory and Critical Care Medicine·Angela SimpsonAdnan Custovic
Jul 28, 2006·The European Respiratory Journal·I RomieuS London
Aug 26, 2006·American Journal of Respiratory and Critical Care Medicine·Gregory A HawkinsEugene R Bleecker
Aug 29, 2006·Lancet·Sabina IlliUNKNOWN Multicentre Allergy Study (MAS) group
Aug 29, 2006·Lancet·Sally E Wenzel
Sep 5, 2006·The Journal of Allergy and Clinical Immunology·Bénédicte LeynaertFrançoise Neukirch
Oct 10, 2006·Current Allergy and Asthma Reports·Aida Semic JusufagicAshley Woodcock
Nov 17, 2006·The European Respiratory Journal·R A RamadasS L Ewart
Nov 25, 2006·The New England Journal of Medicine·Waltraud EderErika von Mutius
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa CameronDonata Vercelli
Jan 5, 2007·Proceedings of the American Thoracic Society·Fernando D Martinez
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Ian A YangKwun M Fong
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Sejal Saglani, Andrew Bush
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Markus Johannes EgeUNKNOWN PARSIFAL Study team

❮ Previous
Next ❯

Citations

Sep 26, 2012·Journal of Clinical Immunology·Tetsuo MorihanaHitoshi Kikutani
Jan 17, 2014·The Lancet. Respiratory Medicine·Daniel W BelskyAvshalom Caspi
Jul 29, 2010·European Journal of Clinical Nutrition·E Rodríguez-RodríguezR M Ortega
Jul 10, 2009·Mucosal Immunology·P MatangkasombutD T Umetsu
Jun 22, 2010·Nature Immunology·Hye Young KimDale T Umetsu
Jun 1, 2011·The Journal of Experimental Medicine·Gerhard WingenderAnthony A Horner
Jan 7, 2010·Current Opinion in Allergy and Clinical Immunology·Donata Vercelli
Aug 21, 2010·Journal of Public Health Management and Practice : JPHMP·James KriegerDarryl C Zeldin
Jan 15, 2010·Annual Review of Public Health·Stavros Garantziotis, David A Schwartz
Mar 26, 2013·BMC Medical Genetics·Yoon-Jeong KimChoon-Sik Park
Jul 5, 2013·Environmental Health : a Global Access Science Source·Marta RavaRachel Nadif
Feb 4, 2012·PloS One·Vera Isabel CasacaBianca Schaub
Feb 10, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Slavica DodigRenata Zrinski-Topić
Dec 19, 2009·Pharmacogenomics·Tristan M SissungJohn F Deeken
Jun 5, 2010·Cancer Informatics·Jimmy T Efird
Feb 23, 2013·Archives of Environmental & Occupational Health·F J Gonzalez-BarcalaB Takkouche
Nov 9, 2010·Annual Review of Physiology·Max A Seibold, David A Schwartz
Jun 4, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Isabel R V HartwigMaike Pincus
Jul 21, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Javier MallolUNKNOWN Latin American ISAAC Group
Jul 17, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gretchen E WhiteEileen Storey
Mar 10, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yue ChenHeidi Liepold
Feb 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Malcolm Nolan Blumenthal
Nov 26, 2015·Current Opinion in Allergy and Clinical Immunology·Lorenzo CosmiFrancesco Annunziato
Nov 11, 2009·The Journal of Investigative Dermatology·Luigi Naldi, Santo Raffaele Mercuri
Jun 13, 2015·Yonsei Medical Journal·Jong-Uk LeeChoon-Sik Park
May 6, 2010·International Journal of Occupational Medicine and Environmental Health·Maciej TarkowskiKrystyna Sitarek
Mar 1, 2016·Allergy, Asthma & Immunology Research·Ji Hyun LeeSang Hyun Cho
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Stanley J Szefler
Apr 23, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·H Joel SchmidtBruce K Rubin
Jun 21, 2011·Immunological Reviews·Thomas A E Platts-Mills, Judith A Woodfolk
Jun 21, 2011·Immunological Reviews·Carole Ober, Tsung-Chieh Yao
Mar 8, 2011·Allergy·L CosmiF Annunziato
Oct 14, 2016·Cell Adhesion & Migration·Daisuke Ito, Atsushi Kumanogoh
Sep 10, 2013·La Presse médicale·Nicole Le MoualRachel Nadif
Mar 7, 2017·Scientific Reports·Isabell HentschkeSusetta Finotto

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