Gene expression alterations in Rocky Mountain elk infected with chronic wasting disease.

Prion
Urmila BasuLe Luo Guan

Abstract

Chronic wasting disease (CWD) is an invariably fatal neurologic disease that naturally infects mule deer, white tailed deer and elk. The understanding of CWD neurodegeneration at a molecular level is very limited. In this study, microarray analysis was performed to determine changes in the gene expression profiles in six different tissues including brain, midbrain, thalamus, spleen, RPLN and tonsil of CWD-infected elk in comparison to non-infected healthy elk, using 24,000 bovine specific oligo probes. In total, 329 genes were found to be differentially expressed (> 2.0-fold) between CWD negative and positive brain tissues, with 132 genes upregulated and 197 genes downregulated. There were 249 DE genes in the spleen (168 up- and 81 downregulated), 30 DE genes in the retropharyngeal lymph node (RPLN) (18 up- and 12 downregulated), and 55 DE genes in the tonsil (21 up- and 34 downregulated). Using Gene Ontology (GO), the DE genes were assigned to functional groups associated with cellular process, biological regulation, metabolic process, and regulation of biological process. For all brain tissues, the highest ranking networks for DE genes identified by Ingenuity Pathway Analysis (IPA) were associated with neurological disease, c...Continue Reading

References

Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Mar 25, 1993·Nature·T SöllnerJ E Rothman
May 3, 1996·Neuroscience Letters·S B CollingJ G Jefferys
Aug 26, 1998·The Biochemical Journal·D R Brown, A Besinger
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Dec 16, 1998·Neurobiology of Disease·A R JohnstonN MacLeod
Aug 9, 2001·Neurobiology of Disease·M DiezT Hökfelt
Apr 6, 2002·Acta Neuropathologica·S HaïkJ J Hauw
May 16, 2002·Acta Neuropathologica·S SisóI Ferrer
Nov 22, 2002·The Veterinary Clinics of North America. Food Animal Practice·Elizabeth S Williams
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·David Coates
Apr 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·T R SprakerB E Powers
Aug 27, 2003·The Journal of Veterinary Medical Science·Mo D Salman
Oct 3, 2003·Journal of Neural Transmission·Y MuramatsuT Araki
Jun 23, 2004·Emerging Infectious Diseases·Ermias D BelayLawrence B Schonberger
Sep 17, 2004·Biochemical and Biophysical Research Communications·Constanze RiemerMichael Baier
May 18, 2005·Journal of Molecular Biology·Alex D GreenwoodChristine Leib-Mösch
Jul 22, 2005·American Journal of Epidemiology·Donald J LehmannPatrick G Kehoe
Sep 8, 2005·Veterinary Pathology·E S Williams
Sep 28, 2005·The Journal of Investigative Dermatology·Clemens EscheLisa A Beck
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrew Whitehead, Douglas L Crawford
Apr 20, 2006·Neurobiology of Aging·Margarita DiezTomas Hökfelt
May 17, 2006·BMC Genomics·Pamela J SkinnerAshley T Haase
Aug 31, 2006·Journal of Virology·Gültekin TamgüneyStanley B Prusiner
Sep 2, 2006·Journal of Neurochemistry·Martin FuhrmannJochen Herms
Sep 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yun XuNabil J Alkayed
Dec 8, 2006·Cellular and Molecular Neurobiology·Karen VanaStefan Weiss
Nov 17, 2007·Neuropathology and Applied Neurobiology·T VoigtländerH Budka
Dec 7, 2007·Biochemical and Biophysical Research Communications·Masaaki TaniguchiStephen S Moore
Apr 17, 2008·Veterinary Research·Carole CrozetSylvain Lehmann
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ni ChengRichard D Ye
Dec 18, 2008·Apoptosis : an International Journal on Programmed Cell Death·Nicola VajenteDaniela Saggioro
Mar 19, 2009·PloS One·Nicholas J HaleyEdward A Hoover
Sep 11, 2009·Nature·Gültekin TamgüneyStanley B Prusiner
Oct 1, 2009·Emerging Infectious Diseases·Brent RaceBruce Chesebro

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