Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22

Proceedings of the National Academy of Sciences of the United States of America
Michael L MimmackSabine Bahn

Abstract

We screened a custom-made candidate gene cDNA array comprising 300 genes. Genes chosen have either been implicated in schizophrenia, make conceptual sense in the light of the current understanding of the disease, or are located on high-susceptibility chromosome locations. The array screen using prefrontal cortex tissue from 10 schizophrenia and 10 control brains revealed robust up-regulation of apolipoprotein L1 (apo L1) by 2.6-fold. The finding was cross-validated in a blinded quantitative PCR study using prefrontal cortex tissue from the Stanley Foundation brain collection, Bethesda, MD. This collection consists of 15 schizophrenia, 15 bipolar disorder, 15 major depression, and 15 control individuals, all 60 brains being well-matched on conventional parameters, with antipsychotic drug exposure in the schizophrenia and bipolar disorder groups. Significant up-regulation of apo L1 gene expression in schizophrenia was confirmed. Using quantitative PCR, expression profiles of other members of the apo L family (apo L2-L6) were investigated, showing that apo L2 and L4 were highly significantly up-regulated in schizophrenia. Results were then confirmed in an independent set of 20 schizophrenia and 20 control brains from Japan and New...Continue Reading

References

Jan 1, 1986·Archives of General Psychiatry·F M BenesE D Bird
Dec 14, 1995·Nature·L Peltonen
Mar 1, 1995·Trends in Neurosciences·N J Rothwell, S J Hopkins
Oct 9, 1995·American Journal of Medical Genetics·S G SchwabM Ackenheil
Jun 16, 1999·European Archives of Psychiatry and Clinical Neuroscience·F Benazzi
Sep 22, 1999·American Journal of Medical Genetics·M Myles-WorsleyW Byerley
Oct 26, 1999·Archives of General Psychiatry·K C MurphyM J Owen
Feb 2, 2000·European Archives of Psychiatry and Clinical Neuroscience·N MüllerM J Schwarz
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·D M HoltzmanS M Paul
Jun 1, 2000·The American Journal of Psychiatry·M C Friedl, N Draijer
Jun 27, 2000·The Journal of Biological Chemistry·E I Posse De ChavesJ E Vance
Jul 29, 2000·Schizophrenia Research·E F TorreyR H Yolken
Oct 12, 2000·Critical Reviews in Neurobiology·M DanikJ Poirier
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R KelsoeH Luebbert
Mar 27, 2001·Current Opinion in Lipidology·J M Dietschy, S D Turley
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·E A ThomasJ G Sutcliffe
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger

❮ Previous
Next ❯

Citations

Dec 14, 2006·Journal of Neural Transmission·Y J LaL He
Jun 1, 2005·Brain Research. Molecular Brain Research·Vibeke Sørensen CattsLouise Helen Lutze-Mann
Mar 10, 2005·Neurobiology of Disease·Deborah HollingsheadKároly Mirnics
Sep 18, 2003·Biological Psychiatry·Brian DeanRalph N Martins
Sep 19, 2003·Lancet·Dmitri TkachevSabine Bahn
Jan 27, 2004·Schizophrenia Research·Marquis P VawterWilliam Byerley
Dec 5, 2009·Journal of Human Genetics·Takeshi OtowaTsukasa Sasaki
May 20, 2006·Nature Reviews. Microbiology·Etienne PaysDavid Pérez-Morga
Nov 20, 2002·Journal of Neurochemistry·Outi KontkanenEero Castrén
May 29, 2008·The Journal of Biological Chemistry·Guanghua WanChien-an A Hu
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Brian DeanElizabeth A Thomas
Jan 20, 2007·Omics : a Journal of Integrative Biology·Adolfo Sequeira, Gustavo Turecki
Apr 20, 2004·Neuroreport·Hajime BabaPiers C Emson
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·K E WilsonC M Morris
May 1, 2008·BMC Genomics·Nikola A BowdenPaul A Tooney
Feb 18, 2012·BMC Neuroscience·Debora A RothmondMaree J Webster
Jul 26, 2012·BMC Neuroscience·Leonora E LongCynthia Shannon Weickert
Nov 26, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Ganesan VenkatasubramanianBangalore N Gangadhar
Nov 20, 2002·Pharmacogenomics·Julia ScheelAlfred Bach
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Orest Hurko, John L Ryan
Mar 23, 2011·Clinical Lipidology·David A ElliottBrett Garner
Oct 16, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Merlin G ButlerAnn M Manzardo
May 10, 2012·FEBS Letters·Chien-An A HuPatricio E Ray
Oct 19, 2011·Pharmacology, Biochemistry, and Behavior·Stephen D GinsbergJohn F Smiley
Aug 10, 2010·Biological Psychiatry·Kanchana JagannathanGodfrey D Pearlson
Jan 27, 2010·Journal of Psychiatric Research·Carlotta E DuncanCynthia Shannon Weickert
Oct 11, 2002·Mayo Clinic Proceedings·Janet L SobellCynthia T McMurray
Jul 7, 2005·Journal of Neurochemistry·Saoussen FtouhJacqueline S de Belleroche
Nov 11, 2008·Annals of the New York Academy of Sciences·Elin Lehrmann, William J Freed
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patrick F SullivanCharles M Perou
Jan 1, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tetsufumi KanazawaIan P Everall
Sep 30, 2010·Neuropathology and Applied Neurobiology·L ZhanJ Nasir

❮ Previous
Next ❯

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here