PMID: 8469020Jan 1, 1993Paper

Gene expression and aging

Mechanisms of Ageing and Development
M K ThakurY Natori

Abstract

Considerable amount of data has accumulated during the past few years showing several changes in gene expression as a function of age. However, the basic mechanism of aging still remains poorly understood. In this review, we have mainly analysed the data pertaining to the hypothesis that aging is associated with genetic instability and have attempted further to highlight the gaps that need to be bridged in order to have a clear picture of the aging phenomenon. Extensive investigations employing new and novel approaches are needed in future to elucidate the intricately interwoven patterns of molecular control that underlie the various aspects of gene expression during aging.

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Citations

Oct 1, 1995·Aging : Clinical and Experimental Research·C Q WangD A Lipschitz
Sep 15, 1995·Mechanisms of Ageing and Development·T J Fabian, T E Johnson
Jan 30, 2004·Neurobiology of Aging·Tarja Porkka-HeiskanenDag Stenberg
Jan 1, 1997·Neurobiology of Aging·A H Nagahara, R J Handa
Sep 5, 2002·Ageing Research Reviews·Gary Brewer
Jan 19, 1999·Annual Review of Microbiology·D SinclairL Guarente
Mar 15, 2012·Ageing Research Reviews·Wengong Wang

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