Abstract
Biological aging is associated with functional deficits at the cellular, organ, and system levels. The pituitary gland, the central organ of the neuroendocrine system, has been shown to play an important role in the aging process. To gain a better understanding of its functional changes with aging, we compared the gene expression profiles of the anterior pituitary of young and old Brown Norway rats, focusing on the major pituitary hormone genes. We also explored the effects of caloric restriction, an intervention shown to delay or inhibit age-associated pathologic and biologic changes in a number of systems and organisms, on the expression of these genes. Of the total of 1176 genes arrayed on each of the six membranes per group that we used, 542 (46%) were detectable in the anterior pituitary of young and old rats. Significance analysis of microarrays (SAM) of these 542 detectable genes revealed 28 genes that changed significantly with age, among which 24 decreased and 4 increased. Among the five major hormone genes on the membrane, growth hormone (GH) and prolactin decreased with age, the glycoprotein hormone common alpha subunit gene increased, and follicle-stimulating hormone-beta subunit (FSH-beta) and thyrotropin-beta (TSH...Continue Reading
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