Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Riikka KiveläHeikki Kainulainen

Abstract

A strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle gene-phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12 high capacity runners (HCRs) and 12 low capacity runners (LCRs) from generation 18 of selection that differed by 615% for maximal treadmill endurance running capacity. On average, LCRs were heavier and had increased blood glucose, insulin, and triglycerides compared with HCRs. HCRs were higher for resting metabolic rate, voluntary activity, serum high density lipoproteins, muscle capillarity, and mitochondrial area. Bioinformatic analysis of skeletal muscle gene expression data revealed that many genes up-regulated in HCRs were related to oxidative energy metabolism. Seven mean mRNA expression centroids, including oxidative phosphorylation and fatty acid metabolism, correlated significantly with several exercise capacity and disease risk phenotypes. These expression-phenotype correlations, together with diminished skeleta...Continue Reading

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Citations

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Methods Mentioned

BETA
ELISA
electrophoresis
PCR

Software Mentioned

BioConductor
DAVID
R
Reactome Skypainter
Datacan
AnalySIS
affy
GSEA
SPSS
Skypainter

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