Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration

Toxicology and Applied Pharmacology
Leire ArbillagaA López de Cerain

Abstract

Ochratoxin A (OTA), a naturally occurring mycotoxin, is nephrotoxic in all animal species tested and is considered a potent renal carcinogen, particularly in male rats. Its mechanism of toxicity is still unknown, although oxidative stress appears to be a plausible mechanism. Therefore, the objective of this study was to identify the biological pathways that are modulated in vivo by OTA in male F344 rats in order to gain further insight into its mechanism of renal toxicity. Rats were gavaged daily with OTA (500 microg/kg bw) and gene expression profiles in target and non-target organs were analyzed after 7 and 21 days administration. As was expected, a time-dependent increase of OTA concentrations was found in plasma, kidney and liver, with the concentrations found in both tissues being quite similar. However, histopathological examinations only revealed changes in kidney; signs of nephrotoxicity involving single cell necrosis and karyomegalic nuclei were observed in the treated rats. The number of differentially expressed genes in kidney was much higher than in liver (541 versus 11 at both time points). Several similarities were observed with other in vivo gene expression data. However, great differences were found with previou...Continue Reading

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Jul 25, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A VettorazziA López de Cerain
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May 17, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ariane VettorazziAdela López de Cerain
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Oct 23, 2018·Experimental and Therapeutic Medicine·Feng-Yi YuanXia-Lian Tang

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