Gene expression demonstrates increased resilience toward harmful inflammatory stimuli in the proliferating epidermis of human skin wounds

Experimental Dermatology
K Markus RoupéOle E Sørensen

Abstract

We examined the epidermal gene expression during the proliferative phase of wound healing. Matrix metalloproteases were the group of proteases most prominently up-regulated in skin wounds, whereas serine protease inhibitors were the most strongly up-regulated protease inhibitors. Furthermore, we found down-regulation of genes involved in the extrinsic pathway of apoptosis. This together with the up-regulation of inhibitors of leukocyte serine proteases likely represents a protective step to ensure survival of keratinocytes in the inflammatory wound environment. The down-regulation of proapoptotic genes in the extrinsic pathway of apoptosis was not accompanied by a down-regulation of receptors indicating that the keratinocytes in skin wounds did not become less responsive to external stimuli. Examining the transcription factor binding sites in the promoters of the most differentially expressed genes between normal skin and skin wounds a significant overrepresentation of binding sites were found for STAT-5, SRY and members of the FOXO-family of transcription factors.

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Citations

Apr 4, 2014·The Journal of Investigative Dermatology·Dara S MissanC Michael DiPersio
Jul 11, 2014·The American Journal of Pathology·Ryoichi MoriIsao Shimokawa
Jul 5, 2011·Archives of Medical Research·Eduardo Guaní-GuerraLuis M Terán
Sep 17, 2014·International Journal of Molecular Sciences·Alhassan HameedaldeenDana T Graves
Nov 6, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Leah C BiggsMartine Dunnwald
Jun 30, 2012·Experimental Dermatology·Jérémy ChéretChristelle Le Gall-Ianotto
Nov 20, 2018·The Australasian Journal of Dermatology·Chaoyang MiaoXiaoyan Zhang
Nov 17, 2020·Journal of Diabetes Research·Yulan Wang, Dana T Graves

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