Gene expression drives the evolution of dominance

Nature Communications
Christian D HuberKirk E Lohmueller

Abstract

Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified. Here, we leverage multiple mating systems in natural populations of Arabidopsis to co-estimate the distribution of fitness effects and dominance coefficients of new amino acid changing mutations. We find that more deleterious mutations are more likely to be recessive than less deleterious mutations. Further, this pattern holds across gene categories, but varies with the connectivity and expression patterns of genes. Our work argues that dominance arises as a consequence of the functional importance of genes and their optimal expression levels.

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Citations

Sep 29, 2018·PLoS Genetics·Kimberly J GilbertLaurent Excoffier
Oct 23, 2018·PLoS Genetics·Bernard Y KimKirk E Lohmueller
Jun 24, 2020·ELife·Jeffrey R AdrionAndrew D Kern
Jan 19, 2019·Molecular Biology and Evolution·Xiao Yi, Antony M Dean
Feb 8, 2020·Molecular Biology and Evolution·Erik Díaz-ValenzuelaAngélica Cibrián-Jaramillo
Jul 19, 2020·Molecular Biology and Evolution·Yixuan KouYongfeng Zhou
Dec 18, 2020·PloS One·Luis Bermúdez-GuzmánAlejandro Leal
Jan 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Franck RapaportEtienne Patin
Feb 9, 2021·Evolution Letters·Christopher C KyriazisKirk E Lohmueller
Feb 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·João C Teixeira, Christian D Huber
Mar 7, 2021·Evolution; International Journal of Organic Evolution·Sylvain Glémin
Jun 20, 2021·Science Advances·Garrett A Roberts KingmanKrishna R Veeramah
May 28, 2021·Molecular Biology and Evolution·Xin HuangRyan N Gutenkunst
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Jul 31, 2021·Molecular Biology and Evolution·Martha Rendón-AnayaPär K Ingvarsson
Dec 31, 2021·Molecular Ecology·Annabel C BeichmanRobert K Wayne
Jan 25, 2022·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Himani SachdevaNick Barton

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Datasets Mentioned

BETA
SRR2040829
GSE80744
34
PRJEB19780
PRJNA284572

Methods Mentioned

BETA
PCA

Software Mentioned

∂a∂i
BWA
GATK
SnpEff
UnifiedGenotyper
MEM
scipy
Picard
lyrata
IndelRealigner

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