Gene expression during development of fetal and adult Leydig cells

Annals of the New York Academy of Sciences
Lei DongRen-Shan Ge

Abstract

In rats and mice, Leydig cells are formed as two morphologically and functionally different generations. The first generation develops in utero, from undifferentiated stem Leydig cells (SLCs) that differentiate into fetal Leydig cells (FLCs). After birth, SLCs that may differ from the fetal SLCs undergo lineage-specific commitment and give rise to adult Leydig cells (ALCs). The intermediates of ALCs first become apparent by day 11 postpartum. These first-appearing intermediates, progenitor Leydig cells (PLCs), are spindle shaped and identifiable as steroidogenic because they express luteinizing hormone receptor (LHR) and 3beta-hydroxysteroid dehydrogenase (3betaHSD). The next step in the transition of PLCs to ALCs is the appearance of the immature Leydig cells (ILCs), most commonly seen in the testis during days 28 to 56 postpartum. ILCs have a more abundant smooth endoplasm reticulum (SER), the network of membranes providing a scaffold for steroidogenic enzyme localization, compared to PLCs, but are considered immature because they secrete higher levels of 5alpha-reduced androgen than testosterone. ILCs undergo a final division before ALC steroidogenic function matures by postnatal day 56. ALCs mark the point of maximum differ...Continue Reading

Citations

Sep 22, 2009·Histochemistry and Cell Biology·Nikoloz TsikoliaAlbert Markus Ricken
Sep 21, 2011·Journal of Molecular Histology·N R Antonio-RubioN Moreno-Mendoza
May 11, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Xiufeng WuMary M Lee
Mar 8, 2013·Biology of Reproduction·Tony DefalcoBlanche Capel
Dec 22, 2015·Biochemical and Biophysical Research Communications·Jian-Qi Wang, Wen-Guang Cao
Mar 1, 2015·Human Reproduction Update·Katja J Teerds, Ilpo T Huhtaniemi
Aug 22, 2014·Biology of Reproduction·Colleen M CarneyJoan S Jorgensen
Oct 19, 2012·Biology of Reproduction·Giulia RicciAngela Catizone
Apr 29, 2014·World Journal of Stem Cells·Takashi YazawaTakanobu Taniguchi
Sep 17, 2019·Andrologia·Enhang LuChunping Zhang
Dec 25, 2010·Birth Defects Research. Part C, Embryo Today : Reviews·Haolin ChenBarry R Zirkin
Jun 6, 2015·Molecular and Cellular Biochemistry·Mikella DaigleLuc J Martin
Oct 31, 2018·Nature Communications·Deepti L Kumar, Tony DeFalco
Feb 13, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Khaled HabasDiana Anderson
Aug 17, 2020·Journal of Physiological Anthropology·Marina ButovskayaOleg Lazebny

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.