Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development

Developmental Biology
Serge NefJean-Dominique Vassalli

Abstract

The primary event in mammalian sexual development is the differentiation of the bipotential gonads into either testes or ovaries. Our understanding of the molecular pathways specifying gonadal differentiation is still incomplete. To identify the initial molecular changes accompanying gonadal differentiation in mice, we have performed a large-scale transcriptional analysis of XX and XY Sf1-positive gonadal cells during sex determination. In both male and female genital ridges, a robust genetic program is initiated pre-dating the first morphological changes of the differentiating gonads. Between E10.5 and E13.5, 2306 genes were expressed in a sex-specific manner in the somatic compartment of the gonads; 1223 were overexpressed in XX embryos and 1083 in XY embryos. Although sexually dimorphic genes were scattered throughout the mouse genome, we identified chromosomal regions hosting clusters of genes displaying similar expression profiles. The cyclin-dependent kinase inhibitors Cdkn1a and Cdkn1c are overexpressed in XX gonads at E11.5 and E12.5, suggesting that the increased proliferation of XY gonads relative to XX gonads may result from the overexpression of cell cycle inhibitors in the developing ovaries. These studies define t...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·Y UradeJ I Morgan
May 9, 1991·Nature·P KoopmanR Lovell-Badge
Apr 1, 1989·Molecular Endocrinology·S ShimasakiN Ling
Jan 1, 1986·Annual Review of Genetics·E M Eicher, L L Washburn
Aug 1, 1995·Nature Genetics·Y W JeskeP Koopman
Mar 1, 1996·Current Biology : CB·M J BitgoodA P McMahon
Mar 5, 1998·Nature·A SwainR Lovell-Badge
Mar 7, 1998·Nature·C S RaymondD Zarkower
May 16, 1998·Human Molecular Genetics·A GreenfieldP Koopman
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·V TöhönenK Nordqvist
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·G MazzocchiG G Nussdorfer
Apr 29, 1996·Physical Review Letters·M BlattE Domany
Jun 24, 1999·Molecular Endocrinology·J A ElvinM M Matzuk
Jul 1, 1999·Genes & Development·C J Sherr, J M Roberts
Mar 8, 2000·Mechanisms of Development·B Capel
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·G GetzE Domany
Jan 11, 2000·Journal of Medical Genetics·J R EngelE R Maher
May 29, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Bullejos, P Koopman
Aug 25, 2001·Mechanisms of Development·A C HouwelingV M Christoffels
Sep 28, 2002·Molecular Endocrinology·Nancy R StallingsKeith L Parker
Nov 13, 2002·Seminars in Reproductive Medicine·Corinne CotinotMarc Fellous
Dec 20, 2002·Bioinformatics·Earl HubbellRui Mei
Jan 18, 2003·Endocrine Research·Nancy R StallingsKeith L Parker
Feb 13, 2003·Nucleic Acids Research·Rafael A IrizarryTerence P Speed
Feb 28, 2003·Biology of Reproduction·Peter J McClive, Andrew H Sinclair

❮ Previous
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Citations

Dec 20, 2011·Asian Journal of Andrology·Kathryn McClellandPeter Koopman
Dec 3, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Tamara J StraussStephen R Hammes
Dec 23, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Annemiek BeverdamPeter Koopman
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Tracy M ClementMichael K Skinner
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Terje SvingenPeter Koopman
Nov 29, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Brigitte Le Magueresse-Battistoni
Mar 26, 2014·Brain Research·Chris ArmoskusHoung-Wei Tsai
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yuna KimBlanche Capel
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jana KoubovaDavid C Page
Aug 6, 2014·Nature Reviews. Endocrinology·Valerie A ArboledaEric Vilain
Feb 13, 2008·PLoS Genetics·Susana M Chuva de Sousa LopesAnne McLaren
May 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Douglas CoveneyBlanche Capel
Oct 18, 2008·Development·Hao TangBlanche Capel
Nov 7, 2008·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·L Lin, J C Achermann
Jun 23, 2009·BMC Developmental Biology·José Elias Garcia-OrtizChris Ottolenghi
Jul 21, 2009·Molecular & Cellular Proteomics : MCP·Katherine EwenPeter Koopman
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Pierre CalvelCharles Pineau
Dec 15, 2010·Biology of Reproduction·Antoine D RollandPeter Koopman
Apr 13, 2011·PloS One·Ziping ZhangRonald B Walter
Sep 21, 2011·Journal of Molecular Histology·N R Antonio-RubioN Moreno-Mendoza
Jun 10, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·P PennekampB Dworniczak
Oct 31, 2009·Journal of Applied Genetics·R P Piprek
Mar 27, 2012·Molecular Biotechnology·Jerry WeiPeter Williamson
Jan 19, 2012·Biologie aujourd'hui·Adrienne BailletCorinne Cotinot
Jul 24, 2013·Annual Review of Genomics and Human Genetics·Ruth M Baxter, Eric Vilain

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