PMID: 18205601Jan 22, 2008Paper

Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages

Biochemistry. Biokhimii︠a︡
O I StepanovaE P Kisseleva

Abstract

Vascular endothelial growth factors VEGF-A and VEGF-C are the main angiogenic factors that control growth of new blood and lymphatic vessels in the organism, and they also possess several immunoregulatory activities. Expression of VEGF-A and VEGF-C mRNA as well as mRNA for VEGF receptors in lymphocytes and macrophages of naive mice was investigated. Using reverse transcription and subsequent polymerase chain reaction, we found that peritoneal macrophages, thymocytes, and lymph node cells constitutively expressed VEGF-A and VEGF-C mRNA. In addition, macrophages were positive for VEGFR-1, VEGFR-2, VEGFR-3, NRP-1, and NRP-2 mRNA, whereas thymocytes and lymph node cells expressed mRNA of the same receptors except VEGFR-1. These data expand our knowledge concerning gene distribution of VEGF receptors in the organism, in particular, among the cells of the immune system. This suggests that, along with their major angiogenic properties, VEGF family members additionally might also perform important mediatory functions within the immune system.

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Citations

Jul 30, 2014·PloS One·Daniella Arêas Mendes-da-CruzOlivier Hermine
Jul 16, 2011·International Journal of Cell Biology·Ekaterina P KisselevaVictoria I Lioudyno
Apr 19, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Li-Fu LiShuen-Kuei Liao
Nov 11, 2011·The Journal of Investigative Dermatology·Makoto SugayaShinichi Sato
Dec 5, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoo-Jin ShinMun-Yong Lee
Jun 2, 2020·Frontiers in Physiology·Pieter R Norden, Tsutomu Kume
Oct 27, 2017·Frontiers in Immunology·Sohini RoyKaustubh Datta
Jan 30, 2021·Scientific Reports·Christian BlumeC A Mueller

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