Gene expression in hepatocellular carcinoma: pilot study of potential transarterial chemoembolization response biomarkers

Journal of Vascular and Interventional Radiology : JVIR
Ron C GabaLeigh C Casadaban

Abstract

To perform a feasibility study to explore the relationship between hepatocellular carcinoma genetics and transarterial chemoembolization treatment response to identify potential biomarkers associated with enhanced treatment efficacy. In this single-institution study, pretreatment hepatocellular carcinoma biopsy specimens for tumors in 19 patients (14 men, five women; mean age, 59 y) treated with chemoembolization between 2007 and 2013 were analyzed for a panel of 60 chemotherapy-sensitivity, hypoxia, mitosis, and inflammatory genes with the QuantiGene Plex 2.0 mRNA detection assay. Demographic, disease, and procedure data and tumor response outcomes were collected. Quantitative mRNA levels were compared based on radiologic response between tumors exhibiting complete response (CR) versus partial response (PR). The study sample included 19 biopsy specimens from tumors (mean size, 3.0 cm; grade 1, n = 6; grade 2, n = 9; grade 3, n = 4) in patients treated with a mean of two conventional chemoembolization sessions. Thirteen and six tumors exhibited CR and PR, respectively, at a mean of 116 days after treatment. Tumors with CR showed a significant increase in (P < .05) or trend toward (P < .1) greater (range, 1.49-3.50 fold) pretrea...Continue Reading

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Citations

Apr 30, 2015·Journal of Vascular and Interventional Radiology : JVIR·Daniel G Maluf, Valeria R Mas
Jan 28, 2017·Journal of Vascular and Interventional Radiology : JVIR·Etay ZivJoseph P Erinjeri
Nov 22, 2016·The Cancer Journal·Etay ZivStephen B Solomon
Dec 15, 2015·Clinical Chemistry·Kati RäsänenUlf-Håkan Stenman
May 27, 2020·Journal of Cellular Physiology·Masoud Nouri-VaskehBehzad Baradaran
Jan 3, 2021·Current Oncology Reports·Amgad M Moussa, Etay Ziv
Apr 4, 2021·Biology·Sreenivasulu Chintala, Rachel A Katzenellenbogen
Jan 10, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Neal BhutianiCharles R Scoggins

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