Gene expression in neurotrauma

Neurological Research
S A Dutcher, Daniel B Michael

Abstract

It has been established that following injury to the central nervous system two types of damage take place, the initial insult and the secondary response to injury. This review will focus on the secondary molecular aspects of neurotrauma. These responses may be either deleterious or have protective effects upon the injured cell population. Molecular responses include the regulation of genes which change cellular architecture, up-regulate of growth factors, induce reparative stress responses, influence apoptosis and regulate the transcriptional process. The purpose of this study is to provide the reader with a brief overview of some of the molecular mechanisms which are activated following a neurological insult.

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Citations

Apr 27, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Daniel B MichaelLouis N Irwin
Nov 11, 2009·The Journal of Trauma·Geoffrey T Desmoulin, Jean-Philippe Dionne
Feb 9, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Thomas W McAllister
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·G LovasL D Hudson
Apr 1, 2003·Annals of Neurology·Simone Di GiovanniAlan I Faden

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis