Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Elizabeth M SnyderBarry T Hinton

Abstract

The tissues of the male reproductive tract are characterized by distinct morphologies, from highly coiled to un-coiled. Global gene expression profiles of efferent ducts, epididymis, and vas deferens were generated from embryonic day 14.5 to postnatal day 1 as tissue-specific morphologies emerge. Expression of homeobox genes, potential mediators of tissue-specific morphological development, was assessed. Twenty homeobox genes were identified as either tissue-enriched, developmentally regulated, or both. Additionally, ontology analysis demonstrated cell adhesion to be highly regulated along the length of the reproductive tract. Regulators of cell adhesion with variable expression between the three tissues were identified including Alcam, various cadherins, and multiple integrins. Immunofluorescence localization of the cell adhesion regulators POSTN and CDH2 demonstrated cell adhesion in the epithelium and mesenchyme of the epididymis may change throughout development. These results suggest cell adhesion may be modulated in a tissue-specific manner, playing an important role in establishing each tissue's final morphology.

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Citations

Jun 18, 2016·Seminars in Immunopathology·Undraga SchagdarsurenginAndreas Meinhardt
Mar 17, 2012·Biology of Reproduction·James A MacLeanMiles F Wilkinson
May 12, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Fabiane de SantiEstela Sasso-Cerri
Sep 25, 2018·Reproduction in Domestic Animals = Zuchthygiene·Maria Júlia B BezerraArlindo A Moura
Jul 31, 2020·ELife·Vera D RinaldiOliver J Rando
Aug 21, 2020·Andrologia·Salah ElbashirAshok Agarwal
Sep 23, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joanne WongSebastian Dworkin
Jan 15, 2021·Differentiation; Research in Biological Diversity·Rex A HessBarry T Hinton

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