PMID: 11335125May 4, 2001Paper

Gene expression in the embryonic Xenopus liver

Mechanisms of Development
A M Zorn, J Mason

Abstract

In recent years, significant progress has been made in uncovering the molecular basis of endoderm specification in Xenopus. Much less is understood, however, about endodermal patterning and how endoderm-derived organs such as the liver are formed. Progress has been hampered by the lack of good molecular markers of presumptive liver tissue. Here, we have examined the embryonic expression of a number of marker genes during liver organogenesis, including the transcription factors hex, sox17alpha, and hnf3beta, as well as a number of proteins specific to the adult liver. Interestingly, sox17alpha appears to specifically mark the gall bladder precursors. At 7 days of development expression of the liver differentiation markers albumin, alpha1-microglobulin/bikunin precursor, fibrinogen, transferrin and transthyretin is restricted to the differentiating liver bud. Surprisingly, however, at 3 days of development most of these genes have a more widespread endodermal expression pattern. In addition to expression in the undifferentiated liver bud they were expressed extensively throughout the presumptive intestinal tissue, which may reflect some general feature of how the hepatic gene program is developmentally regulated.

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Citations

Mar 21, 2003·Developmental Biology·Holly A FieldDidier Y R Stainier
Feb 20, 2003·Mechanisms of Development·Debbie ClementsHugh R Woodland
Aug 14, 2003·Gene Expression Patterns : GEP·Ricardo M B CostaAaron M Zorn
Sep 26, 2009·Cell Death and Differentiation·N De MarcoC Campanella
Aug 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·J B GurdonS Simonsson
Aug 20, 2005·Development, Growth & Differentiation·Kimiko Fukuda, Yutaka Kikuchi
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Samantha J Richardson
May 9, 2012·Gene Expression Patterns : GEP·Gabriel E BertolesiSarah McFarlane
Feb 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Abigale G Lade, Satdarshan P S Monga
Jul 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yan GaoYing Cao
Dec 13, 2005·Seminars in Cell & Developmental Biology·Ira L BlitzMarko E Horb
Nov 9, 2005·Gene Expression Patterns : GEP·Liliam Pineda-SalgadoDaniel S Kessler
Jul 24, 2004·Differentiation; Research in Biological Diversity·Stephanie M M Cossette, Thomas A Drysdale
Feb 5, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tadayoshi HayataKen W Y Cho
Jul 16, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hugh R Woodland, Aaron M Zorn
Feb 9, 2012·Mechanisms of Development·Donghun ShinDidier Y R Stainier
Jan 28, 2003·Current Biology : CB·Marko E HorbJonathan M W Slack
Jan 9, 2013·Mechanisms of Development·Valérie S Langlois, Christopher J Martyniuk
Aug 28, 2007·Developmental Biology·Laura HowardHugh R Woodland
Apr 25, 2006·Developmental Biology·Wei ChengJinrong Peng
Sep 24, 2004·Current Opinion in Genetics & Development·Frederic Lemaigre, Kenneth S Zaret
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anjali D'SouzaAaron M Zorn
May 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Edmond Changkyun ParkJin-Kwan Han
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roong Zhao, Stephen A Duncan
Nov 16, 2005·Proteomics·Carolina ParadaDavid Bueno
Feb 14, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Andrea S ViczianMichael E Zuber
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Mar 10, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kiyoshi Yamauchi

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