Gene expression information improves reliability of receptor status in breast cancer patients

Oncotarget
Michael KennWolfgang Schreiner

Abstract

Immunohistochemical (IHC) determination of receptor status in breast cancer patients is frequently inaccurate. Since it directs the choice of systemic therapy, it is essential to increase its reliability. We increase the validity of IHC receptor expression by additionally considering gene expression (GE) measurements. Crisp therapeutic decisions are based on IHC estimates, even if they are borderline reliable. We further improve decision quality by a responsibility function, defining a critical domain for gene expression. Refined normalization is devised to file any newly diagnosed patient into existing data bases. Our approach renders receptor estimates more reliable by identifying patients with questionable receptor status. The approach is also more efficient since the rate of conclusive samples is increased. We have curated and evaluated gene expression data, together with clinical information, from 2880 breast cancer patients. Combining IHC with gene expression information yields a method more reliable and also more efficient as compared to common practice up to now. Several types of possibly suboptimal treatment allocations, based on IHC receptor status alone, are enumerated. A 'therapy allocation check' identifies patient...Continue Reading

References

Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Feb 13, 2003·Nucleic Acids Research·Rafael A IrizarryTerence P Speed
Feb 13, 2004·Bioinformatics·Laurent GautierRafael A Irizarry
Jun 29, 2004·Virchows Archiv : an International Journal of Pathology·C A WellsUNKNOWN European Working Group for Breast Screening Pathology
Jan 1, 1950·Cancer·W J YOUDEN
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Aug 31, 2006·Methods in Enzymology·Tanya Barrett, Ron Edgar
Nov 2, 2006·Journal of the National Cancer Institute·Meredith M ReganUNKNOWN International Breast Cancer Study Group
Nov 14, 2006·Nucleic Acids Research·Tanya BarrettRon Edgar
Mar 14, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J BergqvistJ Bergh
Feb 26, 2008·Breast Cancer Research and Treatment·Xuesong LuAndrea L Richardson
Jul 3, 2008·Cancer Research·Marcus SchmidtMathias Gehrmann
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine DesmedtChristos Sotiriou
Jul 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Klaus P HoeflichMark R Lackner
Dec 17, 2009·Breast Cancer Research and Treatment·Larissa A KordeJo Anne Zujewski
Jan 8, 2010·Breast Cancer Research : BCR·Gordon C WishartPaul D P Pharoah
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel P SilverJudy E Garber
Feb 23, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jan BudcziesVolker Gekeler
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine DesmedtChristos Sotiriou
Aug 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin FilipitsUNKNOWN EP Investigators
Sep 13, 2011·EMBO Molecular Medicine·Sarah DedeurwaerderFrançois Fuks
Nov 24, 2011·PloS One·Renaud SabatierFrançois Bertucci
Jan 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine DesmedtChristos Sotiriou
May 25, 2012·Medical & Biological Engineering & Computing·F J LopezA Blanco
Aug 9, 2012·Cancer Informatics·Xi ChenJennifer A Pietenpol
Dec 12, 2012·Genome Biology·Guanming Wu, Lincoln Stein
Oct 8, 2013·PloS One·Chi-Cheng HuangEric Y Chuang
Jan 21, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aleix PratJosé Baselga
Sep 12, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D BursteinPowel H Brown
Apr 19, 2015·Breast Cancer Research : BCR·Pascal JézéquelMario Campone

❮ Previous
Next ❯

Citations

Aug 25, 2020·BioMed Research International·Michael KennWolfgang Schreiner
Aug 18, 2018·Breast Cancer Research and Treatment·Michael KennWolfgang Schreiner
Feb 21, 2021·Scientific Reports·Michael KennWolfgang Schreiner

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Software Mentioned

MaxLike
ExMax
Bioconductor
LogReg
ParEst
affy
package

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.