Gene expression links functional networks across cortex and striatum

Nature Communications
Kevin M AndersonAvram J Holmes

Abstract

The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in healt...Continue Reading

References

Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Jan 1, 1970·Brain : a Journal of Neurology·J M Kemp, T P Powell
Jan 1, 1995·Brain Research. Brain Research Reviews·A Parent, L N Hazrati
Dec 8, 1994·The Journal of Comparative Neurology·N RajakumarB A Flumerfelt
Jun 1, 1996·Computers and Biomedical Research, an International Journal·R W Cox
Jul 21, 1997·The Journal of Comparative Neurology·D J HoltC B Saper
Apr 3, 2001·Annual Review of Neuroscience·O Steward, E M Schuman
May 7, 2004·Archives of Physical Medicine and Rehabilitation·Karen Lohmann SiegelLisa G Rider
Jun 29, 2004·NeuroImage·Florent SégonneBruce Fischl
Jul 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matthew A ZapalaCarrolee Barlow
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne N HaberRoberta Calzavara
Apr 13, 2007·IEEE Transactions on Medical Imaging·Florent SégonneBruce Fischl
Oct 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J FrankKent E Hutchison
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jean-Claude DreherKaren Faith Berman
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
May 26, 2009·Nucleic Acids Research·Jing ChenAnil G Jegga
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·David C GlahnJ Blangero
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
Jun 19, 2010·CNS Neuroscience & Therapeutics·Tracey A Baskerville, Alison J Douglas
Jan 22, 2011·PLoS Computational Biology·Leon French, Paul Pavlidis
May 17, 2011·PLoS Computational Biology·Lior WolfEytan Ruppin
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Aug 6, 2011·BMC Bioinformatics·Jeremy A MillerSteve Horvath
Oct 28, 2011·Nature·Hyo Jung KangNenad Sestan
Mar 27, 2012·Neuron·Amy BernardEd S Lein
May 2, 2012·BMC Bioinformatics·Mark R DalmanZhong-Hui Duan
Jun 26, 2012·Neuron·Joshua W Buckholtz, Andreas Meyer-Lindenberg
Jul 27, 2012·Journal of Neurophysiology·Eun Young ChoiRandy L Buckner
Sep 22, 2012·Nature·Michael J HawrylyczAllan R Jones
Mar 21, 2013·Nature Reviews. Neuroscience·Gordon M G Shepherd
May 30, 2013·Nature Genetics·GTEx Consortium
Jun 27, 2013·Nature Neuroscience·Randy L BucknerB T Thomas Yeo
Feb 4, 2014·Genome Biology·Charity W LawGordon K Smyth

Citations

Apr 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·J T BakerAvram J Holmes
Nov 7, 2019·Scientific Reports·Jiahe ZhangLisa Feldman Barrett
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ryan V RautM E Raichle
Apr 28, 2019·International Journal of Molecular Sciences·Ilaria RobertiGianvito Urgese
Jan 19, 2020·Nature Communications·Nicolai FranzmeierAlzheimer’s Disease Neuroimaging Initiative (ADNI)
Dec 25, 2018·Frontiers in Neuroanatomy·Sebastian J Kopetzky, Markus Butz-Ostendorf
Feb 10, 2019·Nature Communications·Daniel S QuintanaLars T Westlye
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kevin M AndersonAvram J Holmes
Aug 6, 2019·Frontiers in Neural Circuits·Aurina ArnatkeviciuteAlex Fornito
Dec 18, 2020·ELife·Golia ShafieiBratislav Misic
Jun 26, 2020·NeuroImage·Joshua B BurtJohn D Murray
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Magdalena MroczekWadid Sirry
Feb 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Kevin M AndersonAvram J Holmes
Jul 20, 2019·Biological Psychiatry·Martijn P van den HeuvelRené S Kahn

Methods Mentioned

BETA
RNAseq

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