The human brain is comprised of a complex web of functional networks that link anatomically distinct regions. However, the biological mechanisms supporting network organization remain elusive, particularly across cortical and subcortical territories with vastly divergent cellular and molecular properties. Here, using human and primate brain transcriptional atlases, we demonstrate that spatial patterns of gene expression show strong correspondence with limbic and somato/motor cortico-striatal functional networks. Network-associated expression is consistent across independent human datasets and evolutionarily conserved in non-human primates. Genes preferentially expressed within the limbic network (encompassing nucleus accumbens, orbital/ventromedial prefrontal cortex, and temporal pole) relate to risk for psychiatric illness, chloride channel complexes, and markers of somatostatin neurons. Somato/motor associated genes are enriched for oligodendrocytes and markers of parvalbumin neurons. These analyses indicate that parallel cortico-striatal processing channels possess dissociable genetic signatures that recapitulate distributed functional networks, and nominate molecular mechanisms supporting cortico-striatal circuitry in healt...Continue Reading
Mosaic distribution of opiate receptors, parafascicular projections and acetylcholinesterase in rat striatum
The neostriatal mosaic: compartmentalization of corticostriatal input and striatonigral output systems
Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex
Walking ability and its relationship to lower-extremity muscle strength in children with idiopathic inflammatory myopathies
The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning
Gene expression of Caenorhabditis elegans neurons carries information on their synaptic connectivity
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder
Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons
Exploiting Gene Expression Profiles for the Automated Prediction of Connectivity between Brain Regions
Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease.
Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.
Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein.
A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems.
Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry.
Correlation between cortical gene expression and resting-state functional network centrality in healthy young adults.
Identifying age-specific gene signatures of the human cerebral cortex with joint analysis of transcriptomes and functional connectomes
Brain Gene Expression Pattern Correlated with the Differential Brain Activation by Pain and Touch in Humans.
Global signal regression strengthens association between resting-state functional connectivity and behavior
Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.
Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data.
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.