Gene expression meta-analysis of Parkinson's disease and its relationship with Alzheimer's disease

Molecular Brain
Jack KellyXinzhong Li

Abstract

Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common neurodegenerative diseases and have been suggested to share common pathological and physiological links. Understanding the cross-talk between them could reveal potentials for the development of new strategies for early diagnosis and therapeutic intervention thus improving the quality of life of those affected. Here we have conducted a novel meta-analysis to identify differentially expressed genes (DEGs) in PD microarray datasets comprising 69 PD and 57 control brain samples which is the biggest cohort for such studies to date. Using identified DEGs, we performed pathway, upstream and protein-protein interaction analysis. We identified 1046 DEGs, of which a majority (739/1046) were downregulated in PD. YWHAZ and other genes coding 14-3-3 proteins are identified as important DEGs in signaling pathways and in protein-protein interaction networks (PPIN). Perturbed pathways also include mitochondrial dysfunction and oxidative stress. There was a significant overlap in DEGs between PD and AD, and over 99% of these were differentially expressed in the same up or down direction across the diseases. REST was identified as an upstream regulator in both diseases. Ou...Continue Reading

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Citations

Mar 25, 2020·Aging·Jack KellyXinzhong Li
Nov 2, 2019·International Journal of Molecular Sciences·Virginie Bottero, Judith A Potashkin
Mar 7, 2020·Communications Biology·Arlin KeoMarcel J T Reinders
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Jun 11, 2021·PloS One·Manuel Seefelder, Stefan Kochanek
Jul 3, 2021·International Journal of Molecular Sciences·Joanna A MotylRobert P Strosznajder

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Datasets Mentioned

BETA
GSE54282

Methods Mentioned

BETA
RNA-seq
chip

Software Mentioned

limma
metaUnion R package
Cytoscape
sva R package
IPA
QIAGEN Ingenuity® Pathway Analysis (
affy microarray suite
nortest R package
R
affy R

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