Gene Expression Meta-Analysis of Potential Metastatic Breast Cancer Markers

Current Molecular Medicine
R BellO Vasieva

Abstract

Breast cancer metastasis is a highly prevalent cause of death for European females. DNA microarray analysis has established that primary tumors, which remain localized, differ in gene expression from those that metastasize. Crossanalysis of these studies allow to revile the differences that may be used as predictive in the disease prognosis and therapy. The aim of the project was to validate suggested prognostic and therapeutic markers using meta-analysis of data on gene expression in metastatic and primary breast cancer tumors. Data on relative gene expression values from 12 studies on primary breast cancer and breast cancer metastasis were retrieved from Genevestigator (Nebion) database. The results of the data meta-analysis were compared with results of literature mining for suggested metastatic breast cancer markers and vectors and consistency of their reported differential expression. Our analysis suggested that transcriptional expression of the COX2 gene is significantly downregulated in metastatic tissue compared to normal breast tissue, but is not downregulated in primary tumors compared with normal breast tissue and may be used as a differential marker in metastatic breast cancer diagnostics. RRM2 gene expression decre...Continue Reading

Citations

May 29, 2020·PLoS Genetics·Christina RossKent Hunter
May 30, 2020·Journal of Cancer Research and Clinical Oncology·Luisa BergerSusanne Beyer
Jul 27, 2020·Journal of Cancer Research and Clinical Oncology·Jairo RamosDeodutta Roy
Jun 17, 2019·Medical Oncology·Raman Preet KaurAnjana Munshi
Mar 8, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xiaowen WangHua Li
Feb 26, 2020·Briefings in Bioinformatics·Daniel Toro-DomínguezPedro Carmona-Sáez
Feb 23, 2020·Frontiers in Cell and Developmental Biology·Emma H van Schie, Renée van Amerongen
Jan 28, 2021·Technology in Cancer Research & Treatment·Yujie WengYingqi Xu
Feb 16, 2021·Frontiers in Cell and Developmental Biology·Yagmur AzbazdarGunes Ozhan
Jul 1, 2021·Journal of Bone Oncology·Kinjal P BhadreshaRakesh M Rawal

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Methods Mentioned

BETA
RNAseq

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