Gene Expression of ABHD6, a Key Factor in the Endocannabinoid System, Can Be Modulated by Female Hormones in Human Immune Cells

Biochemical Genetics
Manuela Nunes DrehmerSara Emelie Löfgren

Abstract

One of the main risk factors for the development of an autoimmune disease is to be a woman. Much attention has been given to the involvement of female hormones in their etiology and sexual bias, although the mechanisms behind this potentially strong contribution in disease susceptibility are poorly understood. ABHD6 gene was recently identified as a risk factor for system lupus erythematosus and the risk was correlated with overexpression of the gene. ABHD6 is an enzyme that degrades the 2-arachidonoylglycerol, an endocannabinoid with immunomodulatory effects. Thus its degradation could contribute to immune dysregulation and development of autoimmune reactions. Sex hormones, such as estrogens, are believed to regulate important genes in the endocannabinoid pathway. However, no study was available regarding the effect of these hormones in human immune cells. In this study, ABHD6 expression was evaluated by quantitative PCR in leukocytes from healthy male and females and in the presence of estrogen or progesterone (PG). A statistical increase in ABHD6 expression could be detected in women. In the presence of estrogen or PG, a statistical upregulation of ABHD6 was observed, and in a sex-dependent manner, as only female cells respo...Continue Reading

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Citations

Feb 8, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oindrila RahamanDipyaman Ganguly
Jul 3, 2021·Journal of Medicinal Chemistry·Giulia BononiCarlotta Granchi

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Methods Mentioned

BETA
electrophoresis
PCR
acetylation

Software Mentioned

Ensembl
GraphPad Prism

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