PMID: 9419740Jan 1, 1994Paper

Gene expression of atrial natriuretic factor in ovine fetal heart during development

Journal of the Society for Gynecologic Investigation
D D JohnsonC Y Cheung

Abstract

The present study quantified the abundance of atrial natriuretic factor (ANF) messenger RNA (mRNA) and determined the developmental pattern of ANF gene expression in the four cardiac chambers of the ovine fetus during the last two-thirds of gestation. Twenty-one fetuses from 13 time-dated pregnant ewes at gestational ages of 60-145 days were used for this study. Total RNA from fetal atria and ventricles was extracted and ANF mRNA was analyzed by Northern blotting. The ANF mRNA signal was quantified by light densitometry. The abundance of ANF mRNA in the cardiac chambers across gestational ages was analyzed by linear regression analysis and one-way analysis of variance. Atrial natriuretic factor mRNA was much more abundant in the atria than in the ventricles of all fetuses at each gestational age studied. Atrial ANF mRNA levels were lowest in the younger fetuses at 60 days and increased with advancing gestation. Ventricular ANF mRNA levels were highest in fetuses at 60 days and decreased to almost nondetectable levels near term. No difference in ANF mRNA abundance was noted between the right and left atria or the right and left ventricles at each gestational age. A developmental pattern of ANF gene expression is demonstrated in ...Continue Reading

References

Dec 1, 1977·American Journal of Obstetrics and Gynecology·N S AssaliB Nuwayhid
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K R ChienS Chien
Mar 15, 1989·Biochemical and Biophysical Research Communications·J J MercadierK Schwartz
Oct 1, 1989·The Journal of Clinical Endocrinology and Metabolism·D G GardnerC F Deschepper
Dec 1, 1986·The Journal of Clinical Endocrinology and Metabolism·T YamajiT Nakayama
May 1, 1987·The Journal of Clinical Investigation·Y F WeiP Needleman
Jun 1, 1987·Acta Endocrinologica·K KikuchiH Mikawa
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C E SeidmanJ G Seidman
Feb 1, 1987·The American Journal of Physiology·J Y CheungJ V Bonventre
Oct 1, 1987·The American Journal of Physiology·M I KotlikoffE E Reynolds

❮ Previous
Next ❯

Citations

May 16, 2002·Journal of Hypertension·Thomas WaltherHolger Stepan
May 16, 2002·Journal of Hypertension·Vicky A Cameron, A Mark Richards
May 15, 2003·Endocrinology·Vicky A Cameron, Leigh J Ellmers
Jun 19, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J GuanZ Xu
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·C Y Cheung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revue médicale de Bruxelles
J DonckierA E Lambert
Anales de medicina interna : organo oficial de la Sociedad Española de Medicina Interna
M C García Calzado, J Millán Núñez-Cortés
© 2021 Meta ULC. All rights reserved