PMID: 8958582Dec 3, 1996Paper

Gene expression of central and peripheral renin-angiotensin system components upon dietary sodium intake in rats

Regulatory Peptides
H JoJ S Park

Abstract

The effects of dietary sodium intake on the gene expression of the renin-angiotensin system (RAS) were investigated in rat central and peripheral tissues in a single set of experiment. Northern and reverse transcriptase-polymerase chain reaction (RT-PCR) techniques were used to detect mRNA expression in rats fed a low- or a high-sodium diet (5 or 500 mmol Na+/kg diet) for 20 days. Plasma and renal renin levels were elevated in rats maintained on the low-sodium diet. Sodium deprivation enhanced the expression of angiotensinogen, renin, AT1A and AT1B receptor subtypes in the hypothalamus, but suppressed them in the brainstem. Kidney and adrenal levels of those mRNAs were also enhanced in the sodium-restricted rats. Both AT1A and AT1B mRNAs changed in a similar magnitude in each tissue examined upon dietary sodium intake. AT1A was the predominant receptor subtype of AT1 in all the tissues examined in the present study except the adrenal gland. The present study demonstrated that dietary sodium modulated the gene expression of the RAS components in the central and peripheral tissues. It also showed that the RAS components in the brainstem and hypothalamus were differentially expressed upon sodium deprivation. This suggests differen...Continue Reading

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Citations

Dec 3, 2003·Trends in Endocrinology and Metabolism : TEM·Elise P Gomez-Sanchez, Celso E Gomez-Sanchez
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Elise P Gomez-Sanchez
Jan 11, 2013·American Journal of Physiology. Renal Physiology·Weijian ShaoL Gabriel Navar
Jul 11, 2009·Neuroendocrinology·Elise P Gomez Sanchez
Sep 26, 2012·Journal of Neuroendocrinology·A S MecawiJ Antunes-Rodrigues
Jul 13, 2004·Experimental Neurology·Yanfang ChenMariana Morris
Nov 13, 2004·The Journal of Physiology·Sophie BédardMichèle Brochu
May 20, 1998·Biochemical and Biophysical Research Communications·K KrishnamurthiK Sandberg
Nov 14, 1997·Frontiers in Neuroendocrinology·E P Gómez-Sánchez
Jun 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H K ParkW J Lee
Jan 31, 2015·Journal of the American Society of Nephrology : JASN·Wei CaoFan Fan Hou
Jan 13, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven J SwensonJames P Porter
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A CharbonneauM G Brunette
May 8, 1999·The American Journal of Physiology·N E Rowland, K R Morian
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Catherine IngertJean-Louis Imbs
Jul 7, 2005·American Journal of Physiology. Renal Physiology·Jazmin M Pérez-RojasNorma A Bobadilla

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