Gene expression of endothelin receptors in aortic cells from cyclosporine-induced hypertensive rats

Clinical and Experimental Pharmacology & Physiology
J IwaiT Takeda

Abstract

1. We examined preproendothelin-1, ETA and ETB receptor mRNA levels in aortic endothelial and smooth muscle cells from cyclosporine (CyA)-induced hypertensive rats using the reverse transcription polymerase chain reaction method. 2. Aortic endothelial preproendothelin-1 mRNA expression was about 1.5-fold higher, while that of ETB receptor mRNA was markedly decreased in CyA-treated rats compared with those in controls. 3. The expression of ETA receptor mRNA in smooth muscle cells from CyA-induced hypertensive rats was increased about two-fold over that in cells from control animals. 4. Thus, increased endothelial preproendothelin-1, and ETA receptor mRNA levels in smooth muscle cells, which are concomitant with the decrease in ETB receptor mRNA levels in endothelium, may contribute to CyA-induced hypertension in rats.

References

Nov 1, 1992·British Journal of Pharmacology·M J SumnerI S Watts
Mar 31, 1992·European Journal of Pharmacology·Y TakedaR Takeda
Jul 15, 1991·Biochemical and Biophysical Research Communications·Y OgawaH Imura
Jan 15, 1991·Biochemical and Biophysical Research Communications·T EmoriF Marumo
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H Y LinH F Lodish
May 31, 1991·Biochemical and Biophysical Research Communications·J G FilepP Sirois
Jul 1, 1991·The Journal of Clinical Investigation·T E Bunchman, C A Brookshire
Feb 1, 1990·Archives of Internal Medicine·G A PorterS G Sheps
Sep 29, 1989·Biochemical and Biophysical Research Communications·W G NaylerP L Mottram
Mar 31, 1989·Biochemical and Biophysical Research Communications·H KuriharaY Yazaki
Aug 11, 1988·Nucleic Acids Research·Y S HoJ D Crapo
Apr 1, 1993·The Journal of Clinical Investigation·Y HirataF Marumo
Jul 1, 1993·The American Journal of Physiology·M ClozelB Butscha
Aug 16, 1993·Biochemical and Biophysical Research Communications·K KannoF Marumo
Feb 1, 1993·The American Journal of Physiology·V K BatraV Gopalakrishnan

❮ Previous
Next ❯

Citations

Jul 3, 2013·Basic & Clinical Pharmacology & Toxicology·Jian-Pu ZhengWen Peng
Jun 1, 1996·Hypertension·B BartholomeuszP A Phillips
Sep 28, 1999·European Journal of Pharmacology·T A MarsenC A Baldamus
Mar 28, 1998·Japanese Journal of Pharmacology·J UchidaT Kishimoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.