Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis

Toxicology and Industrial Health
Yongfei ZhuTianbao Zhang

Abstract

Most previous studies focused on a small number of heat shock proteins (Hsps) and their relationships with embryogenesis, and the actual roles of these Hsps in normal and abnormal embryonic development remain unclear. It was found in the present systemic study that except for Grp170, whose expression was not detectable at GD18, all 19 Hsps of Hsp70, Hsp90 and Hsp110 families were expressed in the normal development of embryonic palate tissue in mice, but their expression patterns varied with different Hsps, presenting as a correlation with the developmental phases. In the treatment group by all-trans retinoic acid (atRA), the messenger RNA (mRNA) abundance of HspA1A, HspA1L, HspA8, HspA9, HspA12A, HspA12B, HspA13, HspA14, Hsp90AA1, Hsp90AB1, Grp94, Trap1, Hsp105, Hsp110 and Grp170 was higher in the palates at GD11 (the beginning of palate development), the mRNA abundance of HspA1A, HspA12A and HspA12B was higher at GD18 (before birth) and an mRNA expression peak of HspA1L, HspA8, HspA9, Hsp90AA1, Grp94, Hsp110 and Grp170 was observed at GD17. The mRNA abundance of most genes in atRA-induced cleft palates of the treatment group was different from that of the control group. Grp78, HspA14 and Hsp105 were closely associated with th...Continue Reading

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Citations

Jul 24, 2012·Cell Stress & Chaperones·Felipe Hiroshi SaitoSteven S Witkin
Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Jul 6, 2014·International Journal of Oncology·Maria Rosaria AmorosoFranca Esposito
Dec 14, 2017·Human & Experimental Toxicology·C RenY Zhu

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Methods Mentioned

BETA
environmental stress
PCR
dissection

Software Mentioned

SPSS

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