Abstract
Most previous studies focused on a small number of heat shock proteins (Hsps) and their relationships with embryogenesis, and the actual roles of these Hsps in normal and abnormal embryonic development remain unclear. It was found in the present systemic study that except for Grp170, whose expression was not detectable at GD18, all 19 Hsps of Hsp70, Hsp90 and Hsp110 families were expressed in the normal development of embryonic palate tissue in mice, but their expression patterns varied with different Hsps, presenting as a correlation with the developmental phases. In the treatment group by all-trans retinoic acid (atRA), the messenger RNA (mRNA) abundance of HspA1A, HspA1L, HspA8, HspA9, HspA12A, HspA12B, HspA13, HspA14, Hsp90AA1, Hsp90AB1, Grp94, Trap1, Hsp105, Hsp110 and Grp170 was higher in the palates at GD11 (the beginning of palate development), the mRNA abundance of HspA1A, HspA12A and HspA12B was higher at GD18 (before birth) and an mRNA expression peak of HspA1L, HspA8, HspA9, Hsp90AA1, Grp94, Hsp110 and Grp170 was observed at GD17. The mRNA abundance of most genes in atRA-induced cleft palates of the treatment group was different from that of the control group. Grp78, HspA14 and Hsp105 were closely associated with th...Continue Reading
References
Oct 1, 1992·Physiological Reviews·W J Welch
Jan 1, 1990·Acta Anatomica·K ShiotaD Neubert
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Nov 1, 1987·Irish Journal of Medical Science·M W Ferguson
Oct 1, 1987·Experimental Cell Research·P G PetroniniA F Borghetti
Jan 1, 1995·Archives of Toxicology·N al-ObaidiS Klug
Jan 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C Haanen, I Vermes
Feb 1, 1997·Cellular and Molecular Life Sciences : CMLS·M T LoonesM Morange
May 8, 1997·Biochemical and Biophysical Research Communications·G SconzoG Ghersi
Nov 18, 1997·Anatomy and Embryology·J A Barnes, I W Smoak
Feb 12, 1998·Cell Structure and Function·T HatayamaK Shiota
Jul 2, 1998·Biochemical and Biophysical Research Communications·J H XueJ Fujita
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·E J de la RosaF de Pablo
Jan 8, 1999·Cell Stress & Chaperones·H MasudaK Nagata
Apr 30, 1999·Physiological Reviews·A L Fink
Jun 26, 2001·Molecular Reproduction and Development·E S Hunter, D J Dix
Aug 3, 2002·Journal of Biochemistry·Nobuyuki YamagishiTakumi Hatayama
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Raviprakash R DugyalaCarole A Kimmel
Nov 16, 2002·Blood·Wendy A G StamsRob Pieters
Jan 28, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sarah E Ali-Khan, Barbara F Hales
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yasuko KitaoSatoshi Ogawa
Feb 28, 2004·Seminars in Cell & Developmental Biology·Patrick H KroneScott R Blechinger
Mar 27, 2004·Molecular Human Reproduction·Sevil CayliGabor Huszar
Mar 23, 2005·Oncogene·Rong ZhangWang Min
Apr 19, 2005·Cell Stress & Chaperones·Tyler G EvansPatrick H Krone
Apr 23, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bela Z Schmidt, David H Perlmutter
May 23, 2006·Toxicology and Applied Pharmacology·Zengli Yu, Ying Xing
Jun 13, 2006·Orthodontics & Craniofacial Research·J GasheguS Louryan
Jul 19, 2006·Molecular and Cellular Biology·Shengzhan LuoAmy S Lee
Sep 14, 2006·Journal of Cell Science·Guang HuVikas P Sukhatme
Apr 3, 2007·PLoS Genetics·Patricia L YeyatiVeronica van Heyningen
May 22, 2007·The Journal of Biological Chemistry·Guoqiang HuaZusen Fan
Jul 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·Xiaobing HanDing Ma
Nov 8, 2007·Genesis : the Journal of Genetics and Development·Daniel D BrownFrank L Conlon
Dec 7, 2007·Theriogenology·S L McElroyW S Hwang
Jul 30, 2008·Cell Stress & Chaperones·Harm H KampingaLawrence E Hightower
Nov 6, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lijun XuRona G Giffard
Jun 6, 2009·Cell Stress & Chaperones·Larry A SonnaJeffrey D Hasday
Jun 26, 2009·Biology of Reproduction·Oleg M AlekseevMichael G O'Rand
Jul 30, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Marianne BarrierPhilip E Mirkes
Oct 13, 2009·Cell Stress & Chaperones·Attila MolvarecJános Rigó
Feb 2, 2010·Toxicology Letters·Yongfei ZhuTianbao Zhang