Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease

Veterinary Immunology and Immunopathology
Silke SchmitzK Allenspach

Abstract

Inflammatory bowel disease (IBD) is a common cause of chronic diarrhoea in dogs. In people, specific cytokine patterns attributed to T cell subsets, especially T helper cell [Th]1, Th17 and regulatory T(reg) cells have emerged in IBD. In contrast, no specific involvement of a distinct T cell subset has been described so far in canine IBD. Thus, the aim of the present study was to assess gene expression of signature cytokines in duodenal tissues from 18 German shepherd dogs with IBD (group 1), 33 dogs of other breeds with IBD (group 2) and 15 control dogs (group 3). Relative quantification of IL-17A, IL-22, IL-10, IFNy and TGFβ was performed. Expression of IL-17A was significantly lower in groups 1 and 2 compared to group 3 (p=0.014), but no difference in the expression of IL-22 (p=0.839), IFNγ (p=0.359), IL-10 (p=0.085) or TGFβ (p=0.551) across groups was detected. Thus, no clear evidence for the involvement of Th-17 signature cytokines in canine IBD at the mRNA level could be shown. The contribution of specific T cell subsets to the pathogenesis of canine IBD warrants further investigation.

References

Jun 2, 2000·Gastroenterology·T KinugasaH C Reinecker
Sep 17, 2003·Clinical and Experimental Immunology·S MelgarM-L Hammarstrom
Dec 7, 2007·Seminars in Immunology·Ivaylo I IvanovDan R Littman
Jan 4, 2008·The Journal of Clinical Investigation·Ken SugimotoAtsushi Mizoguchi
Jan 3, 2009·Immunity·Yun Kyung LeeCasey T Weaver
May 19, 2009·Nature Immunology·William O'ConnorRichard A Flavell
Nov 17, 2009·Neurochemical Research·Wei Shen, Scott K Durum

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Citations

Nov 26, 2013·The Journal of Veterinary Medical Science·Hiroshi OhtaMitsuyoshi Takiguchi
Nov 28, 2012·Veterinary Immunology and Immunopathology·Silke SchmitzKarin Allenspach
Dec 18, 2015·Veterinary Immunology and Immunopathology·Romy M Heilmann, Jan S Suchodolski
Apr 20, 2012·The Veterinary Journal·Brian Catchpole, Karin Allenspach
Aug 21, 2013·Veterinary Immunology and Immunopathology·Hiroshi OhtaMitsuyoshi Takiguchi
Sep 18, 2018·Journal of Veterinary Internal Medicine·Romy M Heilmann, Jörg M Steiner
May 22, 2019·Journal of Veterinary Internal Medicine·Yu TamuraMitsuyoshi Takiguchi
Apr 10, 2015·Veterinary Sciences·Michelle G RittJaime F Modiano
Mar 31, 2021·Inflammatory Bowel Diseases·Juan HernandezBlandine Lieubeau
Oct 27, 2021·Veterinary Clinical Pathology·Karin Allenspach, Jonathan P Mochel

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