Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria

Malaria Journal
Saleh Al-QuraishyFrank Wunderlich

Abstract

The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination-induced survival of blood-stage malaria. Female Balb/c mice were vaccinated with a non-infectious vaccine consisting of plasma membranes isolated in the form of erythrocyte ghosts from P. chabaudi-infected erythrocytes at week 3 and week 1 before infection with P. chabaudi blood-stage malaria. Gene expression microarrays and quantitative real-time PCR were used to investigate the response of the liver, in terms of expression of mRNA and long intergenic non-coding (linc)RNA, to vaccination-induced healing infections and lethal P. chabaudi malaria at early patency on day 4 post infection, when parasitized erythrocytes begin to appear in peripheral blood. In vaccination-induced healing infections, 23 genes were identified to be induced in the liver by > tenfold at p < 0.01. More than one-third were genes known to be involved in erythropoiesis, such as Kel, Rhag, Ahsp, Ermap, Slc4a1, Cldn13 Gata1, and Gfi1b. Another group of > ...Continue Reading

References

Jan 1, 1985·Zeitschrift Für Parasitenkunde·F WunderlichM Helwig
Sep 1, 1988·Infection and Immunity·F WunderlichG Schillinger
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MoritaS Tsukita
Nov 30, 1999·Journal of Leukocyte Biology·M M Van den HeuvelR H Beelen
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 12, 2005·Annals of Tropical Medicine and Parasitology·Y DashS K Wikel
Jun 13, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Susan L PerkinsRichard Carter
Feb 12, 2009·Annals of Tropical Medicine and Parasitology·A B Rupani, A D Amarapurkar
Aug 27, 2009·Genome Biology·Madhu Lal-Nag, Patrice J Morin
Jan 27, 2010·Infection and Immunity·Denis DelicFrank Wunderlich
Oct 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy JacksonStephen J McSorley
Dec 1, 2010·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rhea LongleyPhilippe Gros
Jul 12, 2011·Parasitology Research·Albin FontaineLionel Almeras
Nov 22, 2011·Trends in Parasitology·Robin StephensTracey J Lamb
Dec 23, 2011·Cellular Microbiology·Hernando A Del PortilloMarcus V G Lacerda
Apr 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia M WunderlichF Thomas Wunderlich
Jul 17, 2012·Antioxidants & Redox Signaling·Anders EtzerodtSøren Kragh Moestrup
Sep 20, 2012·Methods in Molecular Biology·Amir Horowitz, Eleanor M Riley
Mar 14, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dan XuShu-han Sun
Jul 6, 2013·Cell·Igor Ulitsky, David P Bartel
Nov 29, 2013·Journal of Cellular and Molecular Medicine·Sanja VignjevićGordana Jovčić
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Qingfeng ChenJianzhu Chen
Feb 5, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kenji TakahashiTushar Patel
Nov 20, 2014·Frontiers in Microbiology·Frank WunderlichMohamed A Dkhil
Jan 17, 2015·Frontiers in Medicine·Luca Quagliata, Luigi M Terracciano
Dec 8, 2015·Cellular & Molecular Immunology·Hui PengZhigang Tian
Feb 10, 2016·Frontiers in Immunology·Frank FasbenderCarsten Watzl
Apr 14, 2016·PLoS Medicine·Roly Gosling, Lorenz von Seidlein

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Citations

Jan 31, 2020·Malaria Journal·Denis DelicMarcos J Araúzo-Bravo
Nov 26, 2019·Immunological Reviews·Martin R GoodierEleanor M Riley

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Datasets Mentioned

BETA
E-MTAB.6494
GSE111110

Methods Mentioned

BETA
feature extraction
PCA
PCR

Software Mentioned

Agilent feature extraction software ( FES )
MathWorks
Bloodlinc
Matlab

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