Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.

BMC Research Notes
Marcus ThomassonR Henriksson

Abstract

Previous studies have revealed altered expression of epidermal growth factor receptor (EGFR)-family members and their endogenous inhibitor leucine-rich and immunoglobulin-like domains 1 (LRIG1) in renal cell carcinoma (RCC). In this study, we analyzed the gene expression levels of EGFR-family members and LRIG1, and their possible associations with clinical parameters in various types of RCC. Gene expression levels of EGFR-family members and LRIG1 were analyzed in 104 RCC samples, including 81 clear cell RCC (ccRCC), 15 papillary RCC (pRCC), and 7 chromophobe RCC (chRCC) by quantitative real-time RT-PCR. Associations between gene expression levels and clinical data, including tumor grade, stage, and patient survival were statistically assessed. Compared to kidney cortex, EGFR was up-regulated in ccRCC and pRCC, LRIG1 and ERBB2 were down-regulated in ccRCC, and ERBB4 was strongly down-regulated in all RCC types. ERBB3 expression did not differ between RCC types or between RCC and the kidney cortex. The expression of the analyzed genes did not correlate with patient outcome. This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed RCC types, whereas down-regulati...Continue Reading

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Citations

Jun 12, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Lorraine J GudasDavid M Nanus
Sep 3, 2014·Acta Oncologica·David LindquistHåkan Hedman
Jul 4, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Malek MeskawiMaxine Sun
Sep 4, 2014·Endocrine-related Cancer·Catalina SimionColleen Sweeney
Jun 27, 2019·JCI Insight·Oghenekevwe M GbenedioPhilippe Depeille
Jun 26, 2018·Frontiers in Oncology·Florinda Meléndez-RodríguezJulian Aragones
Oct 5, 2016·Experimental and Therapeutic Medicine·Xiaofang Jiang, Huiwu Li
May 3, 2013·American Journal of Physiology. Renal Physiology·Alexander StaruschenkoTengis S Pavlov
Jan 22, 2021·Seminars in Cancer Biology·Yibing JiDean G Tang

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