Gene expression patterns as marker for 5-year postoperative prognosis of primary breast cancers

Journal of Cancer Research and Clinical Oncology
Masamitsu OndaYusuke Nakamura

Abstract

To establish the novel prognostic markers for breast cancer, gene expression profile was examined genome-wide. We used cDNA microarray consisting of 18,432 human genes to compare genome-wide expression profiles of eight primary breast cancers, four from patients who died of breast cancer within 5 years after surgery (5D group) and four who survived disease-free for more than 5 years (5S group). We identified 21 genes whose expression was greater in tumors from the 5D group than in 5S tumors, and 23 with higher expression in the 5S group than in the 5D group. We established a Prognostic Index (PI) for prediction of postoperative prognosis, based on the aberrant expression profiles of ten of those genes. Among 20 additional cases chosen blindly, ten presented with high prognostic scores (>7, good) according to the PI; the remaining ten cases revealed scores <7 (poor). The PI predicted the actual 5-year clinical outcomes of these 20 cases with 100% accuracy. Our PI system is reliable in clinical settings for predicting postoperative risk for breast cancer. The extensive list of genes provides valuable information about progression of breast cancer and suggests potential target molecules for treating this disease.

Citations

Jun 9, 2006·Journal of Cancer Research and Clinical Oncology·Dingfeng Jiang, Naiqing Zhao
Sep 28, 2007·Breast Cancer Research and Treatment·Martin LaussChrista Noehammer
Feb 28, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Steven G GrayKenneth J O'Byrne
May 16, 2009·International Journal of Cancer. Journal International Du Cancer·Bradley J ScottCheng E Ng
Jul 25, 2006·Current Problems in Surgery·Christopher A GarcesWilliam G Cance
Aug 29, 2006·Surgery Today·Shin-Ichi AsakaMasamitsu Onda
Nov 3, 2005·Nature Clinical Practice. Oncology·Per Eystein LønningAnne-Lise Børresen-Dale
Mar 27, 2020·Frontiers in Oncology·Qiang WangXiangqian Guo

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