Gene expression patterns in bone following mechanical loading.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Sara M Mantila RoosaCharles H Turner

Abstract

The advent of high-throughput measurements of gene expression and bioinformatics analysis methods offers new ways to study gene expression patterns. The primary goal of this study was to determine the time sequence for gene expression in a bone subjected to mechanical loading during key periods of the bone-formation process, including expression of matrix-related genes, the appearance of active osteoblasts, and bone desensitization. A standard model for bone loading was employed in which the right forelimb was loaded axially for 3 minutes per day, whereas the left forearm served as a nonloaded contralateral control. We evaluated loading-induced gene expression over a time course of 4 hours to 32 days after the first loading session. Six distinct time-dependent patterns of gene expression were identified over the time course and were categorized into three primary clusters: genes upregulated early in the time course, genes upregulated during matrix formation, and genes downregulated during matrix formation. Genes then were grouped based on function and/or signaling pathways. Many gene groups known to be important in loading-induced bone formation were identified within the clusters, including AP-1-related genes in the early-resp...Continue Reading

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Datasets Mentioned

BETA
GSE22286

Methods Mentioned

BETA
PCR
Assay

Software Mentioned

Image
Partek Genomics Suite
IPA
MIAME
Pro Plus
Affymetrix GeneChip Operating System ( GCOS

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