Gene expression profile of adhesion and extracellular matrix molecules during early stages of skeletal muscle regeneration.

Journal of Cellular and Molecular Medicine
Laura C CeafalanMihail E Hinescu

Abstract

Skeletal muscle regeneration implies the coordination of myogenesis with the recruitment of myeloid cells and extracellular matrix (ECM) remodelling. Currently, there are no specific biomarkers to diagnose the severity and prognosis of muscle lesions. In order to investigate the gene expression profile of extracellular matrix and adhesion molecules, as premises of homo- or heterocellular cooperation and milestones for skeletal muscle regeneration, we performed a gene expression analysis for genes involved in cellular cooperation, migration and ECM remodelling in a mouse model of acute crush injury. The results obtained at two early time-points post-injury were compared to a GSE5413 data set from two other trauma models. Third day post-injury, when inflammatory cells invaded, genes associated with cell-matrix interactions and migration were up-regulated. After day 5, as myoblast migration and differentiation started, genes for basement membrane constituents were found down-regulated, whereas genes for ECM molecules, macrophage, myoblast adhesion, and migration receptors were up-regulated. However, the profile and the induction time varied according to the experimental model, with only few genes being constantly up-regulated. Gen...Continue Reading

References

Jan 22, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M CantiniL Vitiello
May 25, 2006·Journal of Cell Science·Corinne SonnetBénédicte Chazaud
Oct 6, 2006·American Journal of Physiology. Cell Physiology·Verónica Contreras-ShannonPaula K Shireman
May 5, 2007·The Journal of Physiology·Gordon L WarrenPetia P Simeonova
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
Mar 4, 2008·The International Journal of Developmental Biology·Malgorzata ZimowskaJerzy Moraczewski
Dec 30, 2009·Arthritis and Rheumatism·Madly BrigitteFabrice Chrétien
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball, S Armando Villalta
May 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sean GillCharles W Frevert
Aug 5, 2010·Journal of Cell Science·Huijie LiuYi-Ping Li
Jul 30, 2011·Skeletal Muscle·Christopher J MannPura Muñoz-Cánoves
Aug 13, 2011·Cellular and Molecular Life Sciences : CMLS·David D Roberts
Dec 2, 2011·Nature Reviews. Drug Discovery·Joon-Il Jun, Lester F Lau
Jun 8, 2013·Nature Communications·Anna UrciuoloPaolo Bonaldo
Jan 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Mary Y ChangCharles W Frevert
Apr 30, 2014·BioMed Research International·Laura Cristina CeafalanMihail Eugen Hinescu
Nov 6, 2014·Glycobiology·Annika Andersson-SjölandGunilla Westergren-Thorsson
May 31, 2015·Journal of Muscle Research and Cell Motility·C Snyman, C U Niesler
Jan 26, 2016·PloS One·David HardyFabrice Chrétien
Apr 5, 2016·Ageing Research Reviews·Jasdeep SainiNasser Al-Shanti
Dec 3, 2016·Journal of Neuromuscular Diseases·Hala S Alameddine, Jennifer E Morgan
Aug 2, 2017·Cell Adhesion & Migration·Laura Cristina CeafalanMihaela Gherghiceanu
Mar 14, 2018·International Journal of Molecular Sciences·F Andrea SassKatharina Schmidt-Bleek
Apr 18, 2018·Journal of Orthopaedic Translation·Wenjun Yang, Ping Hu
Aug 15, 2018·The Journal of Bone and Joint Surgery. American Volume·Masamitsu HaraSeiji Okada
Mar 1, 2016·Journal of Sport and Health Science·Weihua XiaoPeijie Chen

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Citations

May 12, 2021·Neuropathology and Applied Neurobiology·Heike KölbelWerner Stenzel

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Datasets Mentioned

BETA
GSE5413

Methods Mentioned

BETA
light microscopy
Profiler

Software Mentioned

RefFinder
GO
GO Molecular Function
Enrichr
KEGG
Statistical Package for Social Science ( SPSS
GEO2R

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