Gene expression profile of angiogenic factors in pulmonary arteries in COPD: relationship with vascular remodeling

American Journal of Physiology. Lung Cellular and Molecular Physiology
Jéssica García-LucioV I Peinado

Abstract

Pulmonary vessel remodeling in chronic obstructive pulmonary disease (COPD) involves changes in smooth muscle cell proliferation, which are highly dependent on the coordinated interaction of angiogenic-related growth factors. The purpose of the study was to investigate, in isolated pulmonary arteries (PA) from patients with COPD, the gene expression of 46 genes known to be modulators of the angiogenic process and/or involved in smooth muscle cell proliferation and to relate it to vascular remodeling. PA segments were isolated from 29 patients and classified into tertiles, according to intimal thickness. After RNA extraction, the gene expression was assessed by RT-PCR using TaqMan low-density arrays. The univariate analysis only showed upregulation of angiopoietin-2 (ANGPT-2) in remodeled PA (P < 0.05). The immunohistochemical expression of ANGPT-2 correlated with intimal enlargement (r = 0.42, P < 0.05). However, a combination of 10 factors in a multivariate discriminant analysis model explained up to 96% of the classification of the arteries. A network analysis of 46 genes showed major decentralization. In this network, the metalloproteinase-2 (MMP-2) was shown to be the bridge between intimal enlargement and fibrogenic factor...Continue Reading

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Citations

Oct 7, 2016·Clinical and Experimental Pharmacology & Physiology·Tobias HilbertSven Klaschik
Jan 20, 2017·Respiratory Research·Clara E Green, Alice M Turner
Jan 19, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey D MarshallPatty J Lee
Jan 20, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qing LuSharon Rounds
Dec 7, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·C ZhangM Sauler

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