Gene-expression profile of collagen-induced arthritis

Journal of Autoimmunity
Saleh IbrahimHans-Jürgen Thiesen

Abstract

To provide a global analysis of genes involved in the inflammatory process in joints of DBA/1J mice suffering from collagen induced arthritis (CIA) we used oligonucleotide microarrays representing approximately 11,000 genes to determine the gene expression profile of the inflamed paws at peak of disease, and compared them to normal tissue. Peak of disease was determined from clinical evaluation of disease and histopathology of joints. Of the 11,000 genes assayed, 223 showed differential expression of four fold or more (187 upregulated and 36 downregulated). Ninety-five of the genes observed had well-characterized full length sequences in databases, and 128 were unknown (Ests). Inflammation resulted in a profile of increased gene expression of matrix metalloproteinases, immune-related, extra-cellular matrix and cell adhesion molecules, as well as molecules involved in cell division and transcription; differential regulation of molecules involved in signal transduction, protein synthesis and metabolism. Of the 55 genes with known chromosomal locations nine mapped to previously identified QTL, contributing to susceptibility or severity of CIA, i.e. MHC class I, II, Basigin, FAP, Cathepsin K, CD 53, RAF1, glucagon, and retinal taur...Continue Reading

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Citations

Jun 27, 2008·Briefings in Functional Genomics & Proteomics·Antonio G PisabarroLucía Ramírez
Nov 4, 2009·Mediators of Inflammation·Manfred Kunz, Saleh M Ibrahim
Mar 4, 2005·Arthritis Research & Therapy·Vyacheslav A AdarichevTibor T Glant
Jul 1, 2005·Arthritis Research & Therapy·Philip GiererBrigitte Vollmar
Jul 1, 2005·Arthritis Research & Therapy·Kristin BauerSaleh M Ibrahim
Nov 16, 2006·Arthritis Research & Therapy·Stefan BauerChristoph Renner
Jan 8, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Peter LorenzMichael O Glocker
Dec 20, 2012·Clinical & Developmental Immunology·Timea BesenyeiZoltan Szekanecz
Feb 12, 2008·Biochimica Et Biophysica Acta·Pamela O'Brien, Brendan F O'Connor
Nov 28, 2008·Arthritis and Rheumatism·J M MilnerA D Rowan
Dec 8, 2004·Toxicon : Official Journal of the International Society on Toxinology·Chang Shik YinHyeong-Gyun Koh
Oct 14, 2003·FEMS Microbiology Letters·Georgia B Schuller-Levis, Eunkyue Park
Jan 1, 2008·Journal of Inorganic Biochemistry·Shamila S Gunatilleke, Amy M Barrios
Jun 29, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Susana Godina-GonzalezJuan R Velazquez
Nov 12, 2005·Medicinal Research Reviews·Michael O GlockerHans-Jürgen Thiesen
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinhua YuSaleh M Ibrahim
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinhua YuSaleh M Ibrahim
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hillary CrandallJanis J Weis
Apr 11, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter LavermanOtto C Boerman
Aug 6, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tessa van der GeestOtto C Boerman
Jun 23, 2006·Journal of Medicinal Chemistry·Shamila S Gunatilleke, Amy M Barrios

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