Gene expression profile of pulpitis

Genes and Immunity
J C GaliciaA A Khan

Abstract

The cost, prevalence and pain associated with endodontic disease necessitate an understanding of the fundamental molecular aspects of its pathogenesis. This study was aimed to identify the genetic contributors to pulpal pain and inflammation. Inflamed pulps were collected from patients diagnosed with irreversible pulpitis (n=20). Normal pulps from teeth extracted for various reasons served as controls (n=20). Pain level was assessed using a visual analog scale (VAS). Genome-wide microarray analysis was performed using Affymetrix GeneTitan Multichannel Instrument. The difference in gene expression levels were determined by the significance analysis of microarray program using a false discovery rate (q-value) of 5%. Genes involved in immune response, cytokine-cytokine receptor interaction and signaling, integrin cell surface interactions, and others were expressed at relatively higher levels in the pulpitis group. Moreover, several genes known to modulate pain and inflammation showed differential expression in asymptomatic and mild pain patients (⩾30 mm on VAS) compared with those with moderate to severe pain. This exploratory study provides a molecular basis for the clinical diagnosis of pulpitis. With an enhanced understanding ...Continue Reading

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Citations

Oct 31, 2018·Molecular Omics·H StarobovaI Vetter
Jan 25, 2018·Genes and Immunity·Marcia Arenas-HernandezRodrigo Vega-Sanchez
Jan 18, 2019·Journal of Periodontology·Esra Guzeldemir-AkcakanatHakan Savli

Related Concepts

Pulpitis
Nested Case-Control Studies
Integrins
Cytokine
Receptors, Cytokine
MRNA Differential Display
Gene Expression Profiles
Gene Expression
Genes
Inflammation

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